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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Fig. 1

Immunofluorescence characterization of the induced pluripotent stem cells (iPSCs) derived neural progenitor cells. a Representative images of neural progenitor cells (NPCs) from healthy control individuals (ctrl-1–ctrl-4), patients with early-onset familial Alzheimer’s disease (fAD-1–fAD-4), and patients with late-onset sporadic Alzheimer’s disease (sAD-1–sAD-6) stained with Nestin (green), paired box 6 (PAX6; red), and 4′,6-diamidino-2-phenylindole (DAPI; blue). All three groups exhibited similar progenitor marker expression. scale bar = 30 μm. b Flow cytometric analysis of cultured NPCs. Dot plots demonstrate similar expression pattern of PAX6 and Nestin in control, fAD, and sAD iPSC line-derived NPC cultures with similar passage numbers (p6)

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Alzheimer's Research & Therapy

ISSN: 1758-9193