Table 2 Sex-dependent effect in differentiation of neurodegenerative disease s from control by microRNA classifiers
AD-CNTR | FTD-CNTR | PD-CNTR | ALS-CNTR | ||
|---|---|---|---|---|---|
A. miRNA classifiers most effectively differentiating NDs from control in all (male + female) participants | |||||
miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-16 | miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a | miR-9*/miR-129-3p and miR-99b/miR-874 and miR-9*/miR-411 | miR-206/miR-31 and miR-206/miR-125b and miR-99/miR-338-3p | ||
Male + female | AUC | 0.97 | 0.94 | 0.96 | 0.95 |
Accuracy | 0.91 | 0.91 | 0.86 | 0.83 | |
Male | AUC | 0.98 | 0.98 | 0.96 | 0.94 |
Accuracy | 0.92 | 0.94 | 0.88 | 0.9 | |
Female | AUC | 0.97 | 0.91 | 0.96 | 0.95 |
Accuracy | 0.9 | 0.88 | 0.85 | 0.83 | |
B. miRNA classifiers most effectively differentiating NDs from control in male and female groups | |||||
Male | miR-99b/miR-181a and miR-125/miR-874 and miR-9*/miR-29a | miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a | miR-9*/miR-129-3p and miR-99b/miR-146a and miR-9*/miR-204 | miR-206/miR-155 and miR-9*/miR-129-3p and miR-335/miR-338-3p | |
AUC | 0.99 | 0.98 | 0.98 | 0.99 | |
Accuracy | 0.94 | 0.94 | 0.92 | 0.92 | |
Female | miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-451 | miR-491/let-7e and miR-107/miR-9 and miR-28/miR-181a | miR-9*/miR-29a and miR-99b/miR-874 and miR-491/let-7e | miR-206/miR-7 ph2008and miR-9*/miR-125b and miR-491/miR-204 | |
AUC | 0.99 | 0.98 | 0.99 | 0.99 | |
Accuracy | 0.96 | 0.92 | 0.95 | 0.98 | |