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Table 2 Sex-dependent effect in differentiation of neurodegenerative disease s from control by microRNA classifiers

From: Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

   AD-CNTR FTD-CNTR PD-CNTR ALS-CNTR
A. miRNA classifiers most effectively differentiating NDs from control in all (male + female) participants
   miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-16 miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a miR-9*/miR-129-3p and miR-99b/miR-874 and miR-9*/miR-411 miR-206/miR-31 and miR-206/miR-125b and miR-99/miR-338-3p
Male + female AUC 0.97 0.94 0.96 0.95
Accuracy 0.91 0.91 0.86 0.83
Male AUC 0.98 0.98 0.96 0.94
Accuracy 0.92 0.94 0.88 0.9
Female AUC 0.97 0.91 0.96 0.95
Accuracy 0.9 0.88 0.85 0.83
B. miRNA classifiers most effectively differentiating NDs from control in male and female groups
Male   miR-99b/miR-181a and miR-125/miR-874 and miR-9*/miR-29a miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a miR-9*/miR-129-3p and miR-99b/miR-146a and miR-9*/miR-204 miR-206/miR-155 and miR-9*/miR-129-3p and miR-335/miR-338-3p
AUC 0.99 0.98 0.98 0.99
Accuracy 0.94 0.94 0.92 0.92
Female   miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-451 miR-491/let-7e and miR-107/miR-9 and miR-28/miR-181a miR-9*/miR-29a and miR-99b/miR-874 and miR-491/let-7e miR-206/miR-7 ph2008and miR-9*/miR-125b and miR-491/miR-204
AUC 0.99 0.98 0.99 0.99
Accuracy 0.96 0.92 0.95 0.98
  1. Abbreviations: AD Alzheimer’s disease, FTD Frontotemporal dementia, miR MicroRNA, ND Neurodegenerative disease, PD Parkinson’s disease, CNTR Control