Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

Table 2 Sex-dependent effect in differentiation of neurodegenerative disease s from control by microRNA classifiers

		AD-CNTR	FTD-CNTR	PD-CNTR	ALS-CNTR
A. miRNA classifiers most effectively differentiating NDs from control in all (male + female) participants
		miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-16	miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a	miR-9/miR-129-3p and miR-99b/miR-874 and miR-9/miR-411	miR-206/miR-31 and miR-206/miR-125b and miR-99/miR-338-3p
Male + female	AUC	0.97	0.94	0.96	0.95
Male + female	Accuracy	0.91	0.91	0.86	0.83
Male	AUC	0.98	0.98	0.96	0.94
Male	Accuracy	0.92	0.94	0.88	0.9
Female	AUC	0.97	0.91	0.96	0.95
Female	Accuracy	0.9	0.88	0.85	0.83
B. miRNA classifiers most effectively differentiating NDs from control in male and female groups
Male		miR-99b/miR-181a and miR-125/miR-874 and miR-9*/miR-29a	miR-335/let-7e and miR-99b/let-7e and miR-9*/miR-181a	miR-9/miR-129-3p and miR-99b/miR-146a and miR-9/miR-204	miR-206/miR-155 and miR-9*/miR-129-3p and miR-335/miR-338-3p
	AUC	0.99	0.98	0.98	0.99
	Accuracy	0.94	0.94	0.92	0.92
Female		miR-99b/miR-181a and miR-9*/miR-874 and miR-7/miR-451	miR-491/let-7e and miR-107/miR-9 and miR-28/miR-181a	miR-9*/miR-29a and miR-99b/miR-874 and miR-491/let-7e	miR-206/miR-7 ph2008and miR-9*/miR-125b and miR-491/miR-204
	AUC	0.99	0.98	0.99	0.99
	Accuracy	0.96	0.92	0.95	0.98

Abbreviations: AD Alzheimer’s disease, FTD Frontotemporal dementia, miR MicroRNA, ND Neurodegenerative disease, PD Parkinson’s disease, CNTR Control

ISSN: 1758-9193