Table 1 Cohort demographics and clinical data
Diagnosis | Subgroups | No. of subjects | Age (years) | Sex (M/F) | MMSE [NR] | CSF Aβ42 | CSF t-tau | CSF p-tau | Years from diagnosis | Years of education |
|---|---|---|---|---|---|---|---|---|---|---|
Control | N/A | 50 | 64.06 ± 9.8 (25–83) | 24/26 | 29.3 ± 1.0 | N/A | N/A | N/A | N/A | 16.44 ± 2.7 |
AD | N/A | 50 | 67.8 ± 10.4 (53–87) | 24/26 | 21.0 ± 5.6 | 145.7 ± 34.8 | 116.2 ± 68 | 45 ± 23.7 | 3.6 ± 2.2 | 16.5 ± 2.3 |
PD | Total | 50 | 66.76 ± 7.7 (49–82) | 35/15 | 28.9 ± 1.1 [11] | 261.8 ± 49.8 | 43 ± 13.7 | 20.9 ± 7.4 | 10 ± 5.1 | 16.54 ± 2.2 |
Dementia | 15 | 72.33 ± 6.1 (61–82) | 11/4 | 27 [1] | N/A | N/A | N/A | 11 ± 3.9 | 16.33 ± 2.8 | |
MCI | 8 | 68.37 ± 7.0 (54–77) | 5/3 | 29 ± 0.8 [4] | N/A | N/A | N/A | 10.4 ± 7.4 | 16.25 ± 1.7 | |
FTD | Total | 50 | 63.14 ± 6.9 (46–76) | 28/22 | 24.1 ± 5.3 [46] | 271.4 ± 52.3 | 62.2 ± 27.9 | 16.5 ± 7.8 | 3.2 ± 2.3 | 15.96 ± 3.1 |
bv | 23 | 61.69 ± 6.3 (46–74) | 15/8 | 25.3 ± 4.4 | 278.6 ± 52.3 | 57.2 ± 22.5 | 14.5 ± 4.6 | 2.7 ± 2.2 | 16.43 ± 3.0 | |
PPA/Lgpen | 1 | 70 | 1/0 | 22 | 2 | 18 | ||||
PPA/PNFA | 8 | 67.75 ± 4.6 (61–75) | 3/5 | 19.6 ± 9.18 [5] | 269.9 ± 63.5 | 75.2 ± 35.2 | 14.6 ± 4.3 | 4.5 ± 2.1 | 15.2 ± 3.84 | |
PPA/SD | 8 | 61.25 ± 8.4 (49–76) | 4/4 | 22.1 ± 5.19 | 286 ± 48.4 | 79.9 ± 36.6 | 15.9 ± 4.5 | 4 ± 3.0 | 17 ± 2.82 | |
PSP | 10 | 63.6 ± 7.51 (54–75) | 5/5 | 25.6 ± 4.4 | 244.7 ± 46.0 | 50.6 ± 19.5 | 14.5 ± 4.6 | 2.7 ± 1.6 | 14.4 ± 2.99 | |
ALS | Total | 50 | 59.64 ± 10.8 (29–83) | 36/14 | 24.8 ± 7.8 [16] | 240.4 ± 76.3 | 71.1 ± 50.7 | 13.8 ± 6.8 | 1.8 ± 1.8 | 14.71 ± 2.9 |
With FTD | 5 | 65.4 ± 9.18 (49–70) | 4/1 | 14. 3 ± 12.0 [3] | 222.4 ± 88.8 | 107 ± 62.1 | 19 ± 10.1 | 4 ± 4.4 | 15.8 ± 2.3 | |
With MCI | 3 | 57 ± 5.2 (54–63) | 2/1 | 30 [1] | 340 ± 3 | 66 ± 32 | 11.3 ± 0.6 | 1 ± 1 | 13.5 ± 7.8 |