Fig. 1

Differentiation of Alzheimer’s disease (AD) from control by select microRNA (miRNA, miR) pairs and their combination. The performance of three miRNA pairs and resulting signature in the training, confirmation, and combined sets is shown. The table at the bottom of the figure indicates performance of the miRNA classifier in the three sets. The area under the ROC curve (AUC) is presented; sensitivity, specificity, and accuracy of each biomarker/normalizer pair were calculated at the cutoff point with the highest accuracy. In the box-and-whisker plots, the ratios are calculated as 2^−ΔCt × 100, and the results are presented in log₁₀ scale. The upper and lower limits of the boxes and the lines inside the boxes indicate the 75th and 25th percentiles and the median, respectively. The upper and lower horizontal bars denote the 90th and 10th percentiles, respectively. The points indicate assay values located outside 80% of data. AMC Age- and sex-matched controls