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Table 5 Estimated odds ratios for each scenario based on the proportional odds model

From: Attitudes toward clinical trials across the Alzheimer’s disease spectrum

Covariate Low risk, low burden Medium risk, medium burden High risk, high burden
Estimated OR (95% CI) P value Estimated OR (95% CI) P value Estimated OR (95% CI) P value
Diagnosis
 Dementia 1.0   1.0   1.0  
 MCI 0.88 (0.23–3.29) 0.844 0.64 (0.17–2.40) 0.507 0.27 (0.06–1.15) 0.076
 CN 0.30 (0.08–1.09) 0.067 0.21 (0.06–0.77) 0.019 0.12 (0.03–0.54) 0.006
Partner involvement
 Some help 0.65 (0.22–1.96) 0.448 1.12 (0.38–3.30) 0.834 0.58 (0.16–2.11) 0.408
Marital status
 Married (living as) 3.06 (1.12–8.35) 0.029 2.26 (0.82–6.22) 0.114 1.84 (0.63–5.41) 0.266
Gender
 Female 2.04 (0.84–4.97) 0.117 1.99 (0.80–4.95) 0.139 2.64 (0.97–7.17) 0.056
Age (5 years) 1.30 (1.04–1.62) 0.021 1.21 (0.96–1.51) 0.102 1.14 (0.90–1.45) 0.276
Education 0.78 (0.65–0.93) 0.007 0.77 (0.64–0.93) 0.007 0.80 (0.65–0.97) 0.024
  1. CI confidence interval, CN cognitively normal, MCI mild cognitive impairment, OR odds ratio