Fig. 3
Immunohistochemical staining of amyloid-β (Aβ)4–x peptides in sporadic Alzheimer’s disease (AD) cases. With IC16 recognizing full-length Aβ peptides, abundant extracellular (a, c, e) and vascular (a, c) amyloid deposits were detected in sporadic AD brains (a). In contrast, after staining with the Aβ4–x specific 029-2 antibody, immunoreactivity was restricted to blood vessels (b, d) and neuritic plaques (d, f), while diffuse amyloid deposits were completely negative (b). Scale bar = 100 μm (a, b, e, f); 200 μm (c, d)