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Table 1 Domains of measurement, instruments, and descriptions of 6 fixed and 73 time-varying covariates used in the Sullivan life table/longitudinal Grade of Membership model

From: Personalized predictive modeling for patients with Alzheimer’s disease using an extension of Sullivan’s life table model

No. Domain Instrument Count Description of variables
Fixed covariates
Intake assessment 6 ApoE status, sex, age at intake, race, occupation, and years since diagnosis
Time-varying variables
1 Behavior CUSPAD 4 Wandering away, verbal outbursts, physical threats, and difficulty sleeping
2 Cognition MMSE 8 MMSE completion indicator, orientation, registration, “world” backward, recall, language, and drawing
3 Functioning BDRS 22 IADL (8 items), BADL (3 items), and personality (11 items)
4 Dependence Dependence scale 14 Dependence scale (13 items), equivalent institutional care
5 Eyesight/hearing problems Medical questionnaire 2 Adequate sight? Adequate hearing?
6 Acute medical treatments/conditions Patient follow-up questionnaire 3 Admission to hospital, treatment, and had seizure?
7 Psychiatric/psychotic symptoms CUSPAD 3 Delusions, hallucinations, and illusions
8 Alcohol use Alcohol questionnaire 3 Beer/week, wine/week, and hard liquor/week
9 Motor signs/symptoms UPDRS 6 Extrapyramidal signs (summary score), tremor, bradykinesia, gait, myoclonus, and rigidity
10 Depression/agitation CUSPAD 4 Agitation, sadness/depression, depression frequency, and appetite problems
11 Dementia with Lewy body symptoms DLB questionnaire 4 DLB questionnaire completion indicator, fluctuating cognition, and visual hallucinations
  1. Abbreviations: ApoE Apolipoprotein E, BADL Basic activities of daily living, BDRS Blessed Dementia Rating Scale, CUSPAD Columbia University Scale for Psychopathology in Alzheimer’s Disease, DLB Dementia with Lewy bodies, IADL Instrumental activities of daily living, MMSE Mini Mental State Examination, UPDRS Unified Parkinson’s Disease Rating Scale
  2. See [21] for details