Table 1 Domains of measurement, instruments, and descriptions of 6 fixed and 73 time-varying covariates used in the Sullivan life table/longitudinal Grade of Membership model
No. | Domain | Instrument | Count | Description of variables |
|---|---|---|---|---|
Fixed covariates | ||||
– | – | Intake assessment | 6 | ApoE status, sex, age at intake, race, occupation, and years since diagnosis |
Time-varying variables | ||||
1 | Behavior | CUSPAD | 4 | Wandering away, verbal outbursts, physical threats, and difficulty sleeping |
2 | Cognition | MMSE | 8 | MMSE completion indicator, orientation, registration, “world” backward, recall, language, and drawing |
3 | Functioning | BDRS | 22 | IADL (8 items), BADL (3 items), and personality (11 items) |
4 | Dependence | Dependence scale | 14 | Dependence scale (13 items), equivalent institutional care |
5 | Eyesight/hearing problems | Medical questionnaire | 2 | Adequate sight? Adequate hearing? |
6 | Acute medical treatments/conditions | Patient follow-up questionnaire | 3 | Admission to hospital, treatment, and had seizure? |
7 | Psychiatric/psychotic symptoms | CUSPAD | 3 | Delusions, hallucinations, and illusions |
8 | Alcohol use | Alcohol questionnaire | 3 | Beer/week, wine/week, and hard liquor/week |
9 | Motor signs/symptoms | UPDRS | 6 | Extrapyramidal signs (summary score), tremor, bradykinesia, gait, myoclonus, and rigidity |
10 | Depression/agitation | CUSPAD | 4 | Agitation, sadness/depression, depression frequency, and appetite problems |
11 | Dementia with Lewy body symptoms | DLB questionnaire | 4 | DLB questionnaire completion indicator, fluctuating cognition, and visual hallucinations |