Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

Table 4 P values showing pairwise statistical comparisons of single predictor receiver operating characteristic curves based on area under the curve

	Aβ42	Aβ40	p-Tau	t-Tau	MMSE	CDR-sb	CERAD-DR	Aβ42/Aβ40
HCV	ns	0.03	ns	ns	ns	ns	ns	ns
Aβ42		ns	ns	ns	ns	ns	ns	ns
Aβ40			0.02	0.00	0.04	0.02	0.05	0.06
p-Tau				0.03	ns	ns	ns	ns
t-Tau					ns	ns	ns	0.02
MMSE						ns	ns	ns
CDR-sb							ns	ns
CERAD-DR								ns

Significant values are shown in bold typeface
Data were not corrected for multiple testing
For comparing areas under the curve we used a bootstrapping algorithm as implemented in pROC packages (Version 1.8)
Aβ40 amyloid-beta_1–40, Aβ42 amyloid-beta_1–42, CDR-sb Clinical Dementia Rating–sum-of-boxes, CERAD-DR Consortium to Establish a Registry of Dementia–delayed recall, HCV hippocampal volume, MMSE Mini-Mental State Examination, ns not significant, p-Tau phosphorylated tau, t-Tau total tau

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