Skip to main content


Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

Fig. 4

Free water (FW) increases and FW-corrected tissue compartment deterioration correlated with cognitive deficits. a Whole-brain voxel-wise linear regression indicated that increased FW values in widespread brain white matter regions were associated with worse cognitive performance, including attention, executive functioning, visual construction, and visuomotor performance (blue; attention as an example; see also Additional file 1: Table S5). Only FW increase in the left hemisphere was associated with language deficits. Moreover, region-specific FW-corrected tissue compartment damage was associated with deficits in attention, executive functioning (b), visual construction, and visuomotor (c) domains. Results are reported at p < 0.01 significance level, threshold-free cluster enhancement- and family-wise error-corrected. FA T Free water-corrected fractional anisotropy

Back to article page