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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

Fig. 1

Increased free water (FW) in normal-appearing white matter (WM) regions in patients with Alzheimer’s disease (AD) compared with healthy control subjects (HC). a Only patients AD and cerebrovascular disease (AD + CeVD) and patients with vascular dementia (VaD) had higher white matter hyperintensity (WMH) ratios than the patients with AD (##) and HC (**), but patients with AD without CeVD did not differ from HC. b There was increased FW in WM in the patients with AD with and without CeVD and in the patients with VaD compared with the HC (**). The CeVD groups had further FW increases compared with the patients with AD. All data are reported at p < 0.01 corrected. c The patients with AD had widespread FW increases in normal-appearing WM regions compared with the HC, reflecting mild vascular changes (blue). d The patients with AD + CeVD had higher FW than the patients with AD (blue; p < 0.01 threshold-free cluster enhancement- and family-wise error-corrected). The WM skeleton is highlighted in green

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