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Table 3 Intervention effect on nutritional blood markers and homocysteine

From: The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial

Blood outcome parameter

Mean estimated value at week 4

Difference between groups at week 4

p Value for intervention effect

Test (n = 16)

Control (n = 17)

Fatty acids in the erythrocyte membrane

 DHA, %

4.9

2.8

2.1 (1.84 to 2.30)

<0.001

 EPA, %

1.7

0.8

0.8 (0.69 to 0.98)

<0.001

 DPA, %

1.6

1.6

0.014 (−0.12 to 0.15)

0.840

 LC-PUFA (DHA + EPA + DPA), %

8.2

5.3

2.9 (2.51 to 3.24)

<0.001

Fatty acids in blood plasma

 DHA, %

4.4

1.5

2.9 (2.59 to 3.12)

<0.001

 EPA, %

2.1

0.8

1.3 (1.10 to 1.51)

<0.001

 DPA, %

0.50

0.49

0.008 (−0.03 to 0.04)

0.628

 LC-PUFA (DHA + EPA + DPA), %

7.0

2.8

4.2 (3.79 to 4.53)

<0.001

Choline levels in blood plasma, μM

14.4

9.0

5.4 (3.39 to 7.47)

<0.001

Vitamin E levels in blood plasma, μM

50.9

39.6

11.4 (6.77 to 15.96)

<0.001

Homocysteine levels in blood plasma, μM

9.8

12.4

−2.6 (−4.31 to -0.82)

0.006

Uridine levels in blood plasma, μM

14.8

2.6

12.2 (7.24 to 17.11)

<0.001

  1. Abbreviations: DHA Docosahexaenoic acid, EPA Eicosapentaenoic acid, DPA Docosapentaenoic acid, LC-PUFA Long-chain polyunsaturated fatty acids
  2. The 95% CI is presented in parentheses