Fig. 1
Voxel selection and representative examples of 31P and 1H magnetic resonance (MR) spectra. a Voxel selection of 31P-MR spectra displayed on sagittal (left) and coronal (right) anatomical images: anterior cingulate cortex (blue), retrosplenial cortex (yellow), left and right hippocampus (purple). The nominal voxel size is indicated by squares, and the approximation of the effective spherical voxel size is indicated by circles. b Representative 31P-MR spectrum from the retrosplenial cortex. Zero-filling to 4096 data points and an 8-Hz Gaussian filter were applied. c Sagittal (left) and transversal (right) anatomical images showing single-voxel volumes of 1H-MR spectra in anterior cingulate cortex (blue), posterior cingulate cortex (yellow), and voxel selection of left and right hippocampi (purple). d Representative 1H-MR spectrum from the posterior cingulate cortex. Zero-filling to 8192 data points and a 2-Hz Lorentzian filter were applied. PEth, Phosphoethanolamine; PCh, Phosphocholine; Pi, Inorganic phosphate; GPEth, Glycerophosphoethanolamine; GPCh, Glycerophosphocholine; MP, Membrane phospholipids; PCr, Phosphocreatine; ATP, Adenosine triphosphate; NAD(H), Nicotinamide adenine dinucleotide; ppm, Parts per million; NAA, N-acetyl-aspartate; tCho, Choline-containing compounds; tCr, Total creatine; mI, Myo-inositol