Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer’s disease

Table 3 Beta values for predictors of neuropsychological test scores, with model F and R ² values using RSI and DTI metrics

	Regressor	Beta	F value*	R ²
DRS	Arcuate ND Hippocampus IF	0.64 –0.31	16.01	0.62
LMI	Entorhinal IF Arcuate FA	–0.53 0.27	6.64	0.64
LMD	Entorhinal IF Arcuate FA	–0.61 0.23	8.74	0.69
CVLT- SFR	Entorhinal IF Arcuate ND	–0.45 0.34	11.47	0.75
CVLT- LFR	Entorhinal IF Arcuate ND	–0.58 0.28	16.63	0.81
CERAD - DR	Entorhinal IF IFOF FA Fornix FA	–0.49 0.33 0.25	16.44	0.82

Values corrected for age, sex, and education
*All regression models significant at p < 0.001
CERAD-DR Consortium to Establish a Registry for Alzheimer’s Disease delayed recall, CVLT-LFR California Verbal Learning Test long delay free recall, CVLT-SFR California Verbal Learning Test short delay free recall, DRS Dementia Rating Scale, DTI diffusion tensor imaging, FA fractional anisotropy, IF isotropic free water diffusion, IFOF inferior fronto-occipital fasciculus, LMI Logical Memory immediate, LMD Logical Memory delayed, ND neurite density, RSI restriction spectrum imaging

ISSN: 1758-9193