Characteristic | Controls | nfvPPA | svPPA |
---|---|---|---|
General demographic and clinical | |||
 Number (male:female) | 9:10 | 5:5 | 6:3 |
 Age (years) | 69.4 (4.5) | 71.2 (8.9) | 63.8 (4.6)* |
 Handedness (right:left) | 18:1 | 8:2 | 8:1 |
 Education (years) | 15.8 (2.4) | 14.8 (2.9) | 14.9 (2.9) |
 MMSE (/30) | 29.7 (0.6) | 25.6 (4.6) | 19.7 (9.1)* |
 Symptom duration (years) | – | 4.8 (2.8) | 5.3 (2.8) |
 PTA best ear (N:Mild:Mod) | 10:7:0b | 3:5:1a | 5:4:0 |
Background neuropsychological functions | |||
 General intellect: IQ | |||
  WASI verbal IQ | 125.9 (7.3) | 90.7 (21.4) a | 72.3 (18.9) |
  WASI performance IQ | 124.6 (2.5) | 101.2 (7.0) | 102.1 (25.6) |
 Episodic memory | |||
  RMT words (/50) | 49.3 (0.9) | 43.5 (6.3) | 36.0 (8.0) c,* |
  RMT faces (/50) | 45.2 (3.1) | 39.3 (6.1) | 33.3 (6.8) c |
  Camden PAL (/24) | 20.4 (3.3) | 15.8 (6.8) b | 2.2 (3.7)* |
 Working memory | |||
  WMS-R digit span forward (max) | 7.2 (1.2) | 5.1 (0.8) b | 6.0 (1.9) |
  WMS-III spatial span forward (max) | 5.5 (0.8)c | 4.3 (1.1) c, †| 5.4 (0.9) |
 Executive skills | |||
  WASI Block Design (/71) | 45.4 (11.9) | 24.2 (18.9) | 34.6 (24.2) |
  WASI Matrices (/32) | 26.4 (4.1) | 17.4 (8.6) | 19.3 (10.5) |
  WMS-R digit span reverse (max) | 5.6 (1.2) | 3.4 (0.9) b | 4.4 (2.1) |
  WMS-III spatial span reverse (max) | 5.4 (1.0)c | 4.4 (1.5)c | 4.9 (2.0) |
  Letter fluency (F: total) | 16.8 (5.0) | 5.5 (5.8) d | 7.3 (6.5) |
  Category fluency (animals: total) | 23.6 (5.5) | 10.7 (4.3) d | 4.9 (5.8) |
  Trails A (s) | 34.5 (6.8)a | 86.9 (50.0) b | 48.8 (18.2) a |
  Trails B (s) | 72.8 (22.1)a | 192.0 (96.9) d | 123.9 (87.7)a |
 Other skills | |||
  Graded difficulty arithmetic (/24) | 15.3 (5.5) | 5.7 (3.6) c | 11.2 (9.8) |
  VOSP Object Decision (/20) | 19.2 (1.3)a | 15.1 (4.6) a | 16.8 (3.1) a |
Neurolinguistic functions | |||
 Auditory input processing | |||
  PALPA-3 (/36) | 35.8 (0.5)c | 34.0 (2.6) c | 32 (6.5) |
 Word retrieval | |||
  GNT (/30) | 26.4 (2.5) | 17.0 (7.1) a | 1.9 (4.6)* |
 Speech comprehension | |||
  BPVS (/51) | 49.5 (1.3) | 43.4 (5.7) | 10.1 (14.9)* |
  Concrete synonyms (/25) | 24.1 (0.8)c | 21.3 (4.7)c | 14.6 (3.2)* |
  Abstract synonyms (/25) | 24.3 (0.9)c | 21.1 (5.1)c | 15.9 (3.5) c,* |
  PALPA-55 sentences (/24) | 23.8 (0.6)e | 22.1 (3.3)c | 19.7 (6.8) |
 Speech repetition | |||
  Polysyllabic words (/45) | 44.4 (0.9)e | 33.2 (12.0) d | 43.8 (1.6) |
Experimental psychoacoustic tasksf | |||
 Temporal regularity (/20) | 19.5 (1.0) | 18.0 (2.3) | 18.6 (2.7) |
 Phonemic structure (/20) | 18.8 (1.6) | 15.3 (3.4) | 15.6 (1.6) |
 Prosodic predictability (/20) | 19.1 (1.8) | 14.0 (3.1) | 15.0 (4.0) |