Fig. 4
From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism
CAD-31 normalizes the expression of proteins from hippocampal tissue involved in endoplasmic reticulum stress and energy metabolism in old Alzheimer’s disease (AD) mice. a The ratio of phosphorylated eukaryotic initiation factor 2α (PEF2α; PeIF2α) to total eIF2α (TeIF2α). b The ratio of phosphorylated adenosine monophosphate-activated protein kinase (P-AMPK) to total AMPK (TAMPK). c Phosphorylated acetyl-coenzyme A carboxylase 1 (PACC1) to total ACC1 (TACC1). d Ratio of total ACC-1 to glyceraldehyde 3-phosphate dehydrogenase (GAPDH). *** p < 0.001; ** p < 0.01; * p < 0.05; n = 6 per group. C + 31 CAD-31-treated control mice, AD + 31 CAD-31-treated AD APPswe/PS1∆E9 mice, MW Molecular weight