Fig. 9

Reversal of neophobia and short-term spatial memory impairment with P021 in 3 × Tg-AD (Tg-P021) mice. a Neophobia test results. b Sample phase and c test phase of the novel object location task. In the neophobia test mice were exposed to an unfamiliar object in the center of the open-field apparatus for 5 min and the percent of exploration time was recorded. The novel object location test comprised a habituation phase, a sample phase, and a test phase. During habituation, the animals were trained a total of six sessions, two sessions/day, and each session lasted 10 min within 2 h of intertrial interval. The sample phase and the test phase were conducted 24 h after the last habituation session. The test phase was 1 h after the sample phase. The vehicle-treated mice (Tg-AD vh) were impaired in the object location task and P021 was able to prevent this deficit. *p < 0.05, **p < 0.01. Wild-type (WT), n = 20; 3 × Tg-AD-vh, n = 15; 3 × Tg-AD-P021, n = 14. Data are shown as mean ± SD