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Table 2 Primary outcomes: anticholinergic use change scores from baseline to end of studya

From: Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden

  Control group (n = 24) MTM group (n = 25) p value
Unadjusted outcome (mean ± SD)    
 Medication appropriateness index –1.1 ± 3.1 –4.2 ± 5.1 0.02
 Anticholinergic drug scale –0.2 ± 0.9 –1.2 ± 1.6 0.01
 Number of anticholinergic drugs –0.1 ± 0.3 –0.6 ± 0.7 0.004
Adjusted outcomeb (mean ± SEM)
 Medication appropriateness index –1.0 ± 0.9 –3.6 ± 1.1 0.04
 Anticholinergic drug scale –0.2 ± 0.3 –1.0 ± 0.3 0.03
 Number of anticholinergic drugs –0.04 ± 0.03 –0.2 ± 0.1 0.04
  1. aA negative result means a lower measure at the end-of-study visit (improvement in medication appropriateness index, lower anticholinergic drug scale, and fewer medications with anticholinergic properties)
  2. bAdjusted for baseline Clinical Dementia Rating global score. Reduction in number of anticholinergic drugs is also adjusted for number of anticholinergic drugs taken at baseline (as the offset in the Poisson model)