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Table 3 Multiple logistic regression analyses and the association of blood pressure and Alzheimer disease, presented according to split age groups (<60, >60 years) and blood pressure medication status (never or ever)

From: Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

  Never BP medication <60 years old (n = 15 267) Never BP medication >60 years old (n = 3 665) Ever BP medication <60 years old (n = 3 329) Ever BP medication >60 years old (n = 2 173)
OR (95% CI) NCa OR (95% CI) NCa OR (95% CI) NCa OR (95% CI) NCa
HUNT 1 HUNT 2 119 HUNT 1 HUNT 2 144 HUNT 1 HUNT 2 41 HUNT 1 HUNT 2 79
Model 1b             
 SBP 1.21 (1.08–1.34) 1.17 (1.08–1.27)   0.90 (0.82–0.99) 0.93 (0.87–0.99)   1.19 (1.04–1.35) 1.22 (1.06–1.40)   0.89 (0.81–0.99) 0.96 (0.88–1.06)  
 DBP 1.08 (0.90–1.30) 0.98 (0.84–1.15)   0.90 (0.76–1.07) 0.88 (0.77–0.99)   1.11 (0.84–1.48) 0.87 (0.67–1.12)   0.95 (0.77–1.17) 1.01 (0.86–1.18)  
 SBP (with DBP) 1.28 (1.12–1.46) 1.36 (1.22–1.52)   0.90 (0.81–1.00) 0.96 (0.87–1.06)   1.25 (1.06–1.47) 1.44 (1.22–1.69)   0.87 (0.78–0.99) 0.93 (0.82–1.05)  
 DBP (with SBP) 0.85 (0.68–1.06) 0.67 (0.54–0.82)   0.99 (0.82–1.22) 0.92 (0.78–1.09)   0.85 (0.60–1.20) 0.61 (0.45–0.81)   1.09 (0.86–1.40) 1.09 (0.89–1.33)  
 MAP 1.14 (0.96–1.35) 1.15 (1.02–1.31)   0.85 (0.73–0.99) 0.90 (0.80–0.99)   1.20 (0.95–1.51) 1.11 (0.89–1.38)   0.85 (0.71–1.02) 0.98 (0.85–1.13)  
 PP 1.29 (1.12–1.47) 1.35 (1.21–1.50)   0.88 (0.79–0.98) 0.93 (0.85–1.03)   1.26 (1.07–1.48) 1.43 (1.22–1.69)   0.88 (0.78–0.99) 0.93 (0.82–1.05)  
Model 2c             
 SBP 0.98 (0.88–1.10) 0.97 (0.89–1.06)   0.93 (0.84–1.02) 0.94 (0.88–1.01)   1.11 (0.97–1.27) 1.15 (0.99–1.32)   0.92 (0.82–1.02) 0.98 (0.89–1.08)  
 DBP 0.86 (0.71–1.04) 0.89 (0.76–1.04)   0.90 (0.75–1.06) 0.88 (0.77–.99)   1.06 (0.80–1.41) 0.90 (0.70–1.16)   0.93 (0.75–1.15) 1.00 (0.86–1.18)  
 SBP (with DBP) 1.05 (0.92–1.21) 1.04 (.92–1.17)   0.94 (0.84–1.05) 0.98 (0.89–1.08)   1.14 (0.96–1.36) 1.32 (1.11–1.57)   0.91 (0.80–1.03) 0.96 (0.85–1.09)  
 DBP (with SBP) 0.82 (0.64–1.03) 0.85 (0.69–1.05)   0.95 (0.77–1.16) 0.89 (0.75–1.06)   0.90 (0.63–1.28) 0.67 (0.50–0.91)   1.03 (0.80–1.32) 1.05 (0.86–1.29)  
 MAP 0.87 (0.73–1.03) 0.96 (0.84–1.09)   0.87 (0.74–1.01) 0.90 (0.81–1.01)   1.10 (0.87–1.39) 1.07 (0.86–1.32)   0.86 (0.72–1.03) 0.99 (0.86–1.14)  
 PP 1.05 (0.91–1.20) 1.01 (0.90–1.14)   0.92 (0.82–1.03) 0.95 (0.87–1.05)   1.15 (0.97–1.36) 1.31 (1.10–1.56)   0.92 (0.81–1.04) 0.96 (0.84–1.09)  
Model 3d             
 SBP 0.95 (0.88–1.11) 0.97 (0.89–1.06)   0.92 (0.83–1.01) 0.92 (0.86–0.99)   1.11 (0.97–1.28) 1.14 (0.99–1.32)   0.91 (0.82–1.01) 0.98 (0.88–1.08)  
 DBP 0.88 (0.72–1.08) 0.89 (0.76–1.05)   0.90 (0.75–1.08) 0.87 (0.76–0.99)   1.10 (0.82–1.47) 0.92 (0.71–1.20)   0.91 (0.73–1.13) 1.01 (0.85–1.19)  
 SBP (with DBP) 1.05 (0.91–1.20) 1.02 (0.90–1.15)   0.92 (0.82–1.03) 0.95 (0.86–1.05)   1.13 (0.95–1.35) 1.30 (1.09–1.56)   0.91 (0.80–1.03) 0.95 (0.84–1.09)  
 DBP (with SBP) 0.85 (0.66–1.08) 0.87 (0.70–1.09)   0.98 (0.79–1.20) 0.92 (0.77–1.10)   0.94 (0.66–1.36) 0.69 (0.50–0.95)   1.02 (0.79–1.32) 1.06 (0.85–1.32)  
 MAP 0.89 (0.74–1.06) 0.96 (0.84–1.10)   0.86 (0.73–1.01) 0.89 (0.79–0.99)   1.12 (0.89–1.42) 1.08 (0.87–1.35)   0.85 (0.71–1.02) 0.99 (0.85–1.14)  
 PP 1.04 (0.90–1.19) 0.99 (0.88–1.13)   0.89 (0.80–1.00) 0.92 (0.83–1.02)   1.14 (0.96–1.35) 1.29 (1.07–1.54)   0.91 (0.81–1.03) 0.95 (0.83–1.08)  
Model 4e             
 SBP 0.99 (0.88–1.11) 0.97 (0.89–1.06)   0.90 (0.82–0.99) 0.92 (0.85–0.99)   1.11 (0.96–1.28) 1.14 (0.99–1.32)   0.90 (0.81–1.00) 0.96 (0.87–1.06)  
 DBP 0.88 (0.82–1.07) 0.90 (0.76–1.06)   0.89 (0.74–1.06) 0.86 (0.75–0.98)   1.11 (0.82–1.51) 0.91 (0.69–1.19)   0.90 (0.72–1.12) 1.00 (0.85–1.19)  
 SBP (with DBP) 1.05 (0.92–1.21) 1.02 (0.90–1.15)   0.91 (0.81–1.02) 0.91 (0.76–1.09)   1.12 (0.94–1.35) 1.30 (1.09–1.56)   0.90 (0.79–1.02) 0.93 (0.82–1.07)  
 DBP (with SBP) 0.83 (0.65–1.07) 0.88 (0.71–1.09)   0.96 (0.78–1.19) 0.68 (0.76–1.09)   0.96 (0.66–1.40) 0.68 (0.49–0.94)   1.01 (0.78–1.31) 1.08 (0.86–1.35)  
 MAP 0.88 (0.74–1.06) 0.96 (0.84–1.10)   0.84 (0.71–0.99) 0.88 (0.78–0.99)   1.12 (0.88–1.43) 1.08 (0.86–1.35)   0.83 (0.69–1.00) 0.97 (0.83–1.13)  
 PP 1.05 (0.91–1.21) 1.00 (0.88–1.13)   0.89 (0.79–1.00) 0.91 (0.83–1.01)   1.13 (0.95–1.36) 1.27 (1.06–1.53)   0.91 (0.80–1.03) 0.93 (0.81–1.06)  
  1. Abbreviations: BP Blood pressure, DBP Diastolic blood pressure, HUNT 1 Helse Undersøkelse Nord-Trøndelag (1984–1986), HUNT 2 Helse Undersøkelse Nord-Trøndelag (1995–1997), MAP Mean arterial pressure, PP Pulse pressure, SBP Systolic blood pressure
  2. aNumber of Alzheimer disease cases
  3. bModel 1: blood pressure entered alone
  4. cModel 2: blood pressure, SBP, DBP, MAP, and PP entered with age, sex, and education
  5. dModel 3: SBP, DBP, MAP, and PP entered with, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, and pulse
  6. eModel 4: SBP, DBP, MAP, and PP entered with age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status, physical activity, blood pressure medication, and alcohol use
  7. The bold text represents p-value <=.05