|
Never BP medication <60 years old (n = 15 267)
|
Never BP medication >60 years old (n = 3 665)
|
Ever BP medication <60 years old (n = 3 329)
|
Ever BP medication >60 years old (n = 2 173)
|
---|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
---|
HUNT 1
|
HUNT 2
|
119
|
HUNT 1
|
HUNT 2
|
144
|
HUNT 1
|
HUNT 2
|
41
|
HUNT 1
|
HUNT 2
|
79
|
---|
Model 1b
| | | | | | | | | | | | |
SBP
|
1.21 (1.08–1.34)
|
1.17 (1.08–1.27)
| |
0.90 (0.82–0.99)
|
0.93 (0.87–0.99)
| |
1.19 (1.04–1.35)
|
1.22 (1.06–1.40)
| |
0.89 (0.81–0.99)
|
0.96 (0.88–1.06)
| |
DBP
|
1.08 (0.90–1.30)
|
0.98 (0.84–1.15)
| |
0.90 (0.76–1.07)
|
0.88 (0.77–0.99)
| |
1.11 (0.84–1.48)
|
0.87 (0.67–1.12)
| |
0.95 (0.77–1.17)
|
1.01 (0.86–1.18)
| |
SBP (with DBP)
|
1.28 (1.12–1.46)
|
1.36 (1.22–1.52)
| |
0.90 (0.81–1.00)
|
0.96 (0.87–1.06)
| |
1.25 (1.06–1.47)
|
1.44 (1.22–1.69)
| |
0.87 (0.78–0.99)
|
0.93 (0.82–1.05)
| |
DBP (with SBP)
|
0.85 (0.68–1.06)
|
0.67 (0.54–0.82)
| |
0.99 (0.82–1.22)
|
0.92 (0.78–1.09)
| |
0.85 (0.60–1.20)
|
0.61 (0.45–0.81)
| |
1.09 (0.86–1.40)
|
1.09 (0.89–1.33)
| |
MAP
|
1.14 (0.96–1.35)
|
1.15 (1.02–1.31)
| |
0.85 (0.73–0.99)
|
0.90 (0.80–0.99)
| |
1.20 (0.95–1.51)
|
1.11 (0.89–1.38)
| |
0.85 (0.71–1.02)
|
0.98 (0.85–1.13)
| |
PP
|
1.29 (1.12–1.47)
|
1.35 (1.21–1.50)
| |
0.88 (0.79–0.98)
|
0.93 (0.85–1.03)
| |
1.26 (1.07–1.48)
|
1.43 (1.22–1.69)
| |
0.88 (0.78–0.99)
|
0.93 (0.82–1.05)
| |
Model 2c
| | | | | | | | | | | | |
SBP
|
0.98 (0.88–1.10)
|
0.97 (0.89–1.06)
| |
0.93 (0.84–1.02)
|
0.94 (0.88–1.01)
| |
1.11 (0.97–1.27)
|
1.15 (0.99–1.32)
| |
0.92 (0.82–1.02)
|
0.98 (0.89–1.08)
| |
DBP
|
0.86 (0.71–1.04)
|
0.89 (0.76–1.04)
| |
0.90 (0.75–1.06)
|
0.88 (0.77–.99)
| |
1.06 (0.80–1.41)
|
0.90 (0.70–1.16)
| |
0.93 (0.75–1.15)
|
1.00 (0.86–1.18)
| |
SBP (with DBP)
|
1.05 (0.92–1.21)
|
1.04 (.92–1.17)
| |
0.94 (0.84–1.05)
|
0.98 (0.89–1.08)
| |
1.14 (0.96–1.36)
|
1.32 (1.11–1.57)
| |
0.91 (0.80–1.03)
|
0.96 (0.85–1.09)
| |
DBP (with SBP)
|
0.82 (0.64–1.03)
|
0.85 (0.69–1.05)
| |
0.95 (0.77–1.16)
|
0.89 (0.75–1.06)
| |
0.90 (0.63–1.28)
|
0.67 (0.50–0.91)
| |
1.03 (0.80–1.32)
|
1.05 (0.86–1.29)
| |
MAP
|
0.87 (0.73–1.03)
|
0.96 (0.84–1.09)
| |
0.87 (0.74–1.01)
|
0.90 (0.81–1.01)
| |
1.10 (0.87–1.39)
|
1.07 (0.86–1.32)
| |
0.86 (0.72–1.03)
|
0.99 (0.86–1.14)
| |
PP
|
1.05 (0.91–1.20)
|
1.01 (0.90–1.14)
| |
0.92 (0.82–1.03)
|
0.95 (0.87–1.05)
| |
1.15 (0.97–1.36)
|
1.31 (1.10–1.56)
| |
0.92 (0.81–1.04)
|
0.96 (0.84–1.09)
| |
Model 3d
| | | | | | | | | | | | |
SBP
|
0.95 (0.88–1.11)
|
0.97 (0.89–1.06)
| |
0.92 (0.83–1.01)
|
0.92 (0.86–0.99)
| |
1.11 (0.97–1.28)
|
1.14 (0.99–1.32)
| |
0.91 (0.82–1.01)
|
0.98 (0.88–1.08)
| |
DBP
|
0.88 (0.72–1.08)
|
0.89 (0.76–1.05)
| |
0.90 (0.75–1.08)
|
0.87 (0.76–0.99)
| |
1.10 (0.82–1.47)
|
0.92 (0.71–1.20)
| |
0.91 (0.73–1.13)
|
1.01 (0.85–1.19)
| |
SBP (with DBP)
|
1.05 (0.91–1.20)
|
1.02 (0.90–1.15)
| |
0.92 (0.82–1.03)
|
0.95 (0.86–1.05)
| |
1.13 (0.95–1.35)
|
1.30 (1.09–1.56)
| |
0.91 (0.80–1.03)
|
0.95 (0.84–1.09)
| |
DBP (with SBP)
|
0.85 (0.66–1.08)
|
0.87 (0.70–1.09)
| |
0.98 (0.79–1.20)
|
0.92 (0.77–1.10)
| |
0.94 (0.66–1.36)
|
0.69 (0.50–0.95)
| |
1.02 (0.79–1.32)
|
1.06 (0.85–1.32)
| |
MAP
|
0.89 (0.74–1.06)
|
0.96 (0.84–1.10)
| |
0.86 (0.73–1.01)
|
0.89 (0.79–0.99)
| |
1.12 (0.89–1.42)
|
1.08 (0.87–1.35)
| |
0.85 (0.71–1.02)
|
0.99 (0.85–1.14)
| |
PP
|
1.04 (0.90–1.19)
|
0.99 (0.88–1.13)
| |
0.89 (0.80–1.00)
|
0.92 (0.83–1.02)
| |
1.14 (0.96–1.35)
|
1.29 (1.07–1.54)
| |
0.91 (0.81–1.03)
|
0.95 (0.83–1.08)
| |
Model 4e
| | | | | | | | | | | | |
SBP
|
0.99 (0.88–1.11)
|
0.97 (0.89–1.06)
| |
0.90 (0.82–0.99)
|
0.92 (0.85–0.99)
| |
1.11 (0.96–1.28)
|
1.14 (0.99–1.32)
| |
0.90 (0.81–1.00)
|
0.96 (0.87–1.06)
| |
DBP
|
0.88 (0.82–1.07)
|
0.90 (0.76–1.06)
| |
0.89 (0.74–1.06)
|
0.86 (0.75–0.98)
| |
1.11 (0.82–1.51)
|
0.91 (0.69–1.19)
| |
0.90 (0.72–1.12)
|
1.00 (0.85–1.19)
| |
SBP (with DBP)
|
1.05 (0.92–1.21)
|
1.02 (0.90–1.15)
| |
0.91 (0.81–1.02)
|
0.91 (0.76–1.09)
| |
1.12 (0.94–1.35)
|
1.30 (1.09–1.56)
| |
0.90 (0.79–1.02)
|
0.93 (0.82–1.07)
| |
DBP (with SBP)
|
0.83 (0.65–1.07)
|
0.88 (0.71–1.09)
| |
0.96 (0.78–1.19)
|
0.68 (0.76–1.09)
| |
0.96 (0.66–1.40)
|
0.68 (0.49–0.94)
| |
1.01 (0.78–1.31)
|
1.08 (0.86–1.35)
| |
MAP
|
0.88 (0.74–1.06)
|
0.96 (0.84–1.10)
| |
0.84 (0.71–0.99)
|
0.88 (0.78–0.99)
| |
1.12 (0.88–1.43)
|
1.08 (0.86–1.35)
| |
0.83 (0.69–1.00)
|
0.97 (0.83–1.13)
| |
PP
|
1.05 (0.91–1.21)
|
1.00 (0.88–1.13)
| |
0.89 (0.79–1.00)
|
0.91 (0.83–1.01)
| |
1.13 (0.95–1.36)
|
1.27 (1.06–1.53)
| |
0.91 (0.80–1.03)
|
0.93 (0.81–1.06)
| |
-
Abbreviations: BP Blood pressure, DBP Diastolic blood pressure, HUNT 1 Helse Undersøkelse Nord-Trøndelag (1984–1986), HUNT 2 Helse Undersøkelse Nord-Trøndelag (1995–1997), MAP Mean arterial pressure, PP Pulse pressure, SBP Systolic blood pressure
-
aNumber of Alzheimer disease cases
-
bModel 1: blood pressure entered alone
-
cModel 2: blood pressure, SBP, DBP, MAP, and PP entered with age, sex, and education
-
dModel 3: SBP, DBP, MAP, and PP entered with, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, and pulse
-
eModel 4: SBP, DBP, MAP, and PP entered with age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status, physical activity, blood pressure medication, and alcohol use
- The bold text represents p-value <=.05