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Table 5 Results of the stepwise linear regression investigating the association of baseline demographics, cerebrospinal fluid markers and positron emission tomography data, with baseline status and cognitive scores in the cross-sectional cohort

From: Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

Association with Baseline status (CTL, SMC/MCI, AD) Baseline MMSE Baseline CDR Baseline ADAS-cog
  r 2 p Value r 2 p Value r 2 p Value r 2 p Value
Sex 0.04 <0.001 0.04 <10−4 0.04 <0.001 0.08 <10−8
Age   ns 0.03 0.003   ns 0.04 <0.001
ApoE4   ns   ns   ns   ns
Baseline CSF
 Aβ1–42   ns   ns   ns   ns
 Tau 0.06 <10−5 0.10 <10−9 0.07 <10−7 0.12 <10−11
 p-Tau181   ns   ns   ns   ns
 p-Tau/Aβ   ns   ns   ns   ns
Baseline PET
 SUVr (pons) 0.18 <10−19(*) 0.14 <10−15 0.14 <10−15 0.18 <10−24
 SUVr (crb) 0.10 <10−6(*) 0.02 0.03 (*)   ns 0.05 0.001 (*)
 SUVr (comp) 0.17 <10−17 0.14 <10−14(*) 0.14 <10−14(*) 0.19 <10−23(*)
  1. Abbreviations: AD Alzheimer’s disease, ADAS-cog Alzheimer’s Disease Assessment Scale–Cognitive Subscale, ApoE Apolipoprotein E, CDR Clinical Dementia Rating, Comp Composite, Crb Cerebellar, CSF Cerebrospinal fluid, MCI Mild cognitive impairment, MMSE Mini Mental State Examination, Pons Pontine, SMC Significant memory complaint, SUVr Standardised uptake value ratio, ns Not significant
  2. All p values are corrected for multiple comparisons
  3. (*): Remained an independent determinant when evaluated jointly