|
Association with
|
Baseline status (CTL, SMC/MCI, AD)
|
Baseline MMSE
|
Baseline CDR
|
Baseline ADAS-cog
|
|---|
| |
r
2
|
p Value
|
r
2
|
p Value
|
r
2
|
p Value
|
r
2
|
p Value
|
|---|
|
Sex
|
0.04
|
<0.001
|
0.04
|
<10−4
|
0.04
|
<0.001
|
0.08
|
<10−8
|
|
Age
| |
ns
|
0.03
|
0.003
| |
ns
|
0.04
|
<0.001
|
|
ApoE4
| |
ns
| |
ns
| |
ns
| |
ns
|
|
Baseline CSF
|
|
Aβ1–42
| |
ns
| |
ns
| |
ns
| |
ns
|
|
Tau
|
0.06
|
<10−5
|
0.10
|
<10−9
|
0.07
|
<10−7
|
0.12
|
<10−11
|
|
p-Tau181
| |
ns
| |
ns
| |
ns
| |
ns
|
|
p-Tau/Aβ
| |
ns
| |
ns
| |
ns
| |
ns
|
|
Baseline PET
|
|
SUVr (pons)
|
0.18
|
<10−19(*)
|
0.14
|
<10−15
|
0.14
|
<10−15
|
0.18
|
<10−24
|
|
SUVr (crb)
|
0.10
|
<10−6(*)
|
0.02
|
0.03 (*)
| |
ns
|
0.05
|
0.001 (*)
|
|
SUVr (comp)
|
0.17
|
<10−17
|
0.14
|
<10−14(*)
|
0.14
|
<10−14(*)
|
0.19
|
<10−23(*)
|
-
Abbreviations: AD Alzheimer’s disease, ADAS-cog Alzheimer’s Disease Assessment Scale–Cognitive Subscale, ApoE Apolipoprotein E, CDR Clinical Dementia Rating, Comp Composite, Crb Cerebellar, CSF Cerebrospinal fluid, MCI Mild cognitive impairment, MMSE Mini Mental State Examination, Pons Pontine, SMC Significant memory complaint, SUVr Standardised uptake value ratio, ns Not significant
- All p values are corrected for multiple comparisons
- (*): Remained an independent determinant when evaluated jointly
