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Table 5 Mean receptor densities in midcingulate area 24' of control subjects and progressive supranuclear palsy patients

From: Multireceptor fingerprints in progressive supranuclear palsy

  Progressive supranuclear palsy vs. control subjects Progressive supranuclear palsy, frontal vs. nonfrontal presentation Progressive supranuclear palsy, mild vs. severe tau pathology
Receptor Control subjects Patients p Value Frontal Nonfrontal p Value Mild Severe p Value
AMPA 731 (39) 739 (246) 0.899 681 (216) 785 (271) 0.421 695 (314) 773 (191) 0.546
Kainate 1129 (182) 1138 (150) 0.880 1102 (162) 1166 (144) 0.422 1161 (166) 1120 (145) 0.602
NMDA 1290 (102) 1455 (188) 0.007 1531 (155) 1397 (198) 0.164 1404 (272) 1495 (79) 0.350
mGlu2/3 7932 (1816) 8576 (1960) 0.361 8462 (1215) 8665 (2464) 0.845 8136 (2647) 8918 (1283) 0.448
GABAA 1975 (188) 2125 (241) 0.070 2078 (204) 2162 (272) 0.506 2232 (323) 2042 (112) 0.181
GABAB 4089 (484) 5126 (801) <0.001 4826 (360) 5360 (982) 0.176 5322 (1155) 4974 (376) 0.406
BZ 2686 (296) 3094 (1028) 0.164 2676 (525) 3419 (1226) 0.158 3567 (1373) 2726 (468) 0.165
pBZ 1698 (227) 2380 (416) <0.001 2444 (257) 2330 (402) 0.605 2452 (464) 2325 (394) 0.564
M1 621 (62) 505 (175) 0.023 581 (186) 446 (150) 0.131 458 (204) 542 (150) 0.358
M2 277 (43) 306 (43) 0.076 285 (29) 322 (47) 0.094 323 (54) 293 (29) 0.185
M3 1071 (84) 1135 (127) 0.117 1137 (142) 1133 (122) 0.959 1123 (129) 1144 (132) 0.752
nACh 116 (40) 102 (40) 0.325 104 (47) 100 (35) 0.833 111 (38) 94 (41) 0.425
α1 705 (57) 805 (174) 0.042 803 (204) 807 (159) 0.963 802 (195) 808 (167) 0.949
α2 1124 (190) 1288 (220) 0.039 1342 (201) 1246 (237) 0.407 1337 (221) 1250 (225) 0.453
5-HT1A 542 (53) 630 (119) 0.017 660 (99) 606 (133) 0.380 621 (172) 636 (65) 0.817
5-HT2 817 (74) 963 (170) 0.006 999 (192) 934 (158) 0.471 1001 (177) 933 (169) 0.446
D1 125 (22) 143 (25) 0.050 157 (17) 132 (26) 0.050 136 (29) 149 (21) 0.307
D2 71 (17) 92 (41) 0.092 75 (19) 104 (49) 0.165 107 (57) 80 (18) 0.191
A1 1300 (151) 1476 (318) 0.069 1542 (407) 1424 (241) 0.479 1413 (281) 1525 (352) 0.504
A2A 120 (9) 134 (30) 0.089 142 (24) 128 (35) 0.392 133 (38) 134 (26) 0.941
  1. Abbreviations: A 1 Adenosine receptor type 1, A 2A Adenosine receptor type 2A, α 1 Adrenoceptor type 1, α 2 Adrenoceptor type 2, AMPA α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, BZ γ-Aminobutyric acid type A-associated benzodiazepine-binding site, D1 Dopamine receptor type 1, D2 Dopamine receptor type 2, GABA A γ-Aminobutyric acid receptor type A, GABA B γ-Aminobutyric acid receptor type B, 5-HT 1A Serotonin receptor type 1A, 5-HT 2 Serotonin receptor type 2, M 1 , M 2 , M 3 Muscarinic cholinergic receptor types 1, 2, 3, mGlu2/3 Metabotropic glutamate receptor type 2/3, nACh Nicotinic cholinergic receptor of the α42 type, NMDA N-methyl-d-aspartate, pBZ Peripheral benzodiazepine receptor
  2. Absolute densities (SD) in femtomoles per milligram of protein as well as p values for the post hoc tests (significant values are highlighted in boldface type) are provided for each receptor type. Note that although comparison of mild versus severe tau pathology resulted in a nonsignificant omnibus test, results of the post hoc tests are displayed