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Table 2 Prevalence of antipsychotic prescribing and concomitant psychotropic medications across years from 2010 to 2014

From: Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study

   2010 2011 2012 2013 2014
   n (%) n (%) n (%) n (%) n (%)
At least one antipsychotic prescribing
 Overall No 43,742 (93.5) 55,898 (92.9) 63,758 (92.9) 68,369 (92.7) 71,853 (92.3)
Yes 3,039 (6.5) 4,301 (7.1) 4,907 (7.2) 5,400 (7.3) 6,013 (7.7)
Total 46,781   60,199   68,665   73,769   77,866  
 Alzheimer’s disease No 30,123 (93.4) 38,513 (92.9) 43,454 (93.0) 45,857 (92.8) 47,180 (92.4)
Yes 2,146 (6.7) 2,954 (7.1) 3,276 (7.0) 3,549 (7.2) 3,871 (7.6)
Total 32,269   41,467   46,730   49,406   51,051  
 Mixed dementia No 10,011 (93.8) 12,669 (92.6) 14,599 (92.5) 15,928 (92.5) 17,208 (92.0)
Yes 661 (6.2) 1,006 (7.4) 1,184 (7.5) 1,299 (7.5) 1,491 (8.0)
Total 10,672   13,675   15,783   17,227   18,699  
 Vascular dementia No 3,608 (94.0) 4,716 (93.3) 5,705 (92.7) 6,584 (92.3) 7,465 (92.0)
Yes 232 (6.0) 341 (6.7) 447 (7.3) 552 (7.7) 651 (8.0)
Total 3,840   5,057   6,152   7,136   8,116  
Psychotropic associations among patients receiving at least one antipsychotic prescribing
 Antipsychotic only 1,002 (33.0) 1,248 (29.0) 1,471 (30.0) 1,676 (31.0) 1,722 (28.6)
 Antipsychotic + hypnotic 153 (5.0) 174 (4.1) 217 (4.4) 215 (4.0) 205 (3.4)
 Antipsychotic + hypnotic + antidepressant 134 (4.4) 208 (4.8) 192 (3.9) 215 (4.0) 228 (3.8)
 Antipsychotic + antidepressant 639 (21.0) 976 (22.7) 1,07 (21.8) 1,142 (21.2) 1,285 (21.4)
 Antipsychotic + anxiolytic 377 (12.4) 531 (12.4) 619 (12.6) 680 (12.6) 739 (12.3)
 Antipsychotic + anxiolytic + hypnotic 106 (3.5) 125 (2.9) 148 (3.0) 172 (3.2) 202 (3.4)
 Antipsychotic + anxiolytic + antidepressant 463 (15.2) 767 (17.8) 895 (18.2) 982 (18.2) 1,222 (20.3)
 Antipsychotic + anxiolytic + hypnotic + antidepressant 165 (5.4) 272 (6.3) 295 (6.0) 318 (5.9) 410 (6.8)
Anti-dementia agents among patients receiving at least one antipsychotic prescribing
 NMDA antagonist No 1,756 (57.8) 2,865 (66.6) 3,556 (72.5) 3,981 (73.7) 3,933 (65.4)
Yes 1,283 (42.2) 1,436 (33.4) 1,351 (27.5) 1,419 (26.3) 2,080 (34.6)
 ChEI No 1,433 (47.2) 1,981 (46.1) 2,588 (52.7) 3,323 (61.5) 3,443 (57.3)
Yes 1,606 (52.9) 2,320 (53.9) 2,319 (47.3) 2,077 (38.5) 2,570 (42.7)
 ChEI + NMDA antagonist No 2,473 (81.4) 3,616 84.1 4,345 (88.6) 4,946 (91.6) 5,227 (86.9)
Yes 566 (18.6) 685 15.9 562 (11.4) 454 (8.4) 786 (13.1)
Total 3,039   4,301   4,907   5,400   6,013  
  1. ChEI cholinesterase inhibitors, NMDA N-methyl-D-aspartate receptor