Fig. 5

Axial, sagittal and coronal views of the 2% strongest connections in brain space of a global, fronto-temporal, and fronto-occipital network (rows 1–3, respectively), demonstrated to drive the group difference between subjects who display both APOE-e4 expression and memory decline versus the remaining sample. Brain regions are shown as nodes (spheres) where their size represents their degree and the color code matches the algebraic sign of relative node strength (red and yellow for positive, green, turquoise and blue for negative). Connections follow the same color scheme