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Table 2 Detailed information of the correlation between brain amyloid deposition (global PiB deposition (SUVR)) and MPP-Aβs

From: Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

 

CN

MCI

ADD

ND

CI

PiB–

PiB+

All

(n = 215)

(n = 79)

(n = 59)

(n = 294)

(n = 138)

(n = 253)

(n = 100)

(n = 353)

MPP-Aβ42

P = 0.7982

**P < 0.01

P = 0.3132

P = 0.9827

P = 0.1125

P = 0.9750

P = 0.7965

P = 0.1776

r = 0.0175

r = 0.3479

r = –0.1336

r = –0.0012

r = 0.1357

r = 0.0020

r = –0.0261

r = –0.0719

MPP-Aβ40

*P = 0.0301

**P < 0.01

P = 0.6639

***P < 0.001

**P < 0.01

P = 0.8155

P = 0.2436

****P < 0.0001

r = 0.1479

r = 0.2950

r = 0.0578

r = 0.2177

r = 0.2272

r = –0.0147

r = 0.1177

r = 0.2309

MPP-Aβ42/40

# P = 0.0940

P = 0.6395

P = 0.2868

**P < 0.01

P = 0.6488

P = 0.7416

P = 0.4437

****P < 0.0001

r = –0.1145

r = 0.0535

r = –0.1410

r = –0.1654

r = –0.0391

r = –0.0208

r = –0.0775

r = –0.2280

  1. SUVR standard uptake value ratio, MPP-Aβ MPP-treated plasma β-amyloid, CN cognitively normal, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, ND nondemented group (CN plus MCI), CI cognitively impaired group (MCI plus ADD), PiB– or PiB+ subjects with negative or positive amyloid deposition, All complete study cohort
  2. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 and Pearson r values by Pearson’s correlation analysis (two-tailed)
  3. # P < 0.10, trend toward significance
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Alzheimer's Research & Therapy

ISSN: 1758-9193