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Table 2 Detailed information of the correlation between brain amyloid deposition (global PiB deposition (SUVR)) and MPP-Aβs

From: Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

  CN MCI ADD ND CI PiB– PiB+ All
(n = 215) (n = 79) (n = 59) (n = 294) (n = 138) (n = 253) (n = 100) (n = 353)
MPP-Aβ42 P = 0.7982 **P < 0.01 P = 0.3132 P = 0.9827 P = 0.1125 P = 0.9750 P = 0.7965 P = 0.1776
r = 0.0175 r = 0.3479 r = –0.1336 r = –0.0012 r = 0.1357 r = 0.0020 r = –0.0261 r = –0.0719
MPP-Aβ40 *P = 0.0301 **P < 0.01 P = 0.6639 ***P < 0.001 **P < 0.01 P = 0.8155 P = 0.2436 ****P < 0.0001
r = 0.1479 r = 0.2950 r = 0.0578 r = 0.2177 r = 0.2272 r = –0.0147 r = 0.1177 r = 0.2309
MPP-Aβ42/40 # P = 0.0940 P = 0.6395 P = 0.2868 **P < 0.01 P = 0.6488 P = 0.7416 P = 0.4437 ****P < 0.0001
r = –0.1145 r = 0.0535 r = –0.1410 r = –0.1654 r = –0.0391 r = –0.0208 r = –0.0775 r = –0.2280
  1. SUVR standard uptake value ratio, MPP-Aβ MPP-treated plasma β-amyloid, CN cognitively normal, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, ND nondemented group (CN plus MCI), CI cognitively impaired group (MCI plus ADD), PiB– or PiB+ subjects with negative or positive amyloid deposition, All complete study cohort
  2. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 and Pearson r values by Pearson’s correlation analysis (two-tailed)
  3. # P < 0.10, trend toward significance
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Alzheimer's Research & Therapy

ISSN: 1758-9193