Skip to main content

Table 1 Baseline demographic information for each of the treatment groups in the three analyses

From: Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease

  A. Simvastatin trial re-analyses B. Continual use of statins (trials from the integrated dataset) C. Continual use of statins (ROS/MAP dataset)
Simvastatin arm Original placebo arm New (pooled) placebo arm Statin users Statin nonusers Statin users Statin nonusers
Number of subjects 171 169 460 600 793 346 513
Age (mean, years)a 73.3 ± 9.8 SD 74.5 ± 8.9 SD 75.0 ± 8.6 SD 76 ± 7.5 SD 76.7 ± 8.4 SD 81.8 ± 6.6 SD 82.5 ± 6.7 SD
Gender (% female) 57.7 60.5 58.9 49.8 59.5 74.3 69.0
Education (mean, years)a 14.5 ± 2.9 14.2 ± 3.3 SD 14.2 ± 3.3 SD 14.0 ± 3.1 SD 14.0 ± 3.1 SD 15.9 ± 3.6 SD 16.3 ± 3.8 SD
Race (%)a 91.7 white and 5.8 black or African American 93.2 white and 5.6 black or African American 91.2 white and 5.4 black or African American 91.8 white and 5.7 black or African American 89.9 white and 6.9 black or African American 91.0 white and 7.5 black or African American 94.9 white and 4.9 black or African American
ApoE4 carriers (%)a 61.8 55.0 60.2 66.7 62.1 37.5 31.8
Mean baseline cognitive measure 24.2 ± 9.4 SD (ADAS-cog) 24.0 ± 10.0 SD (ADAS-cog) 23.9 ± 9.3 SD (ADAS-cog) 23.5 ± 9.6 SD (ADAS-cog) 24.9 ± 9.4 SD (ADAS-cog) 25.3 ± 5.3 SD (MMSE) –0.5 ± 0.8 SD (global cognitive scores) 25.4 ± 4.0 SD (MMSE) –0.55 ± 0.8 SD (global cognitive scores)
  1. A demographic information for the simvastatin trial re-analyses treatment arms, B demographic information for treatment groups used in the analysis of continual use of statins (in five studies from the integrated clinical studies dataset), C demographic information for treatment groups used in the analysis of statins use in the ROS/MAP datasets
  2. ADAS-cog Alzheimer’s Disease Assessment Scale—cognitive subscale, MAP Memory Aging Project, MMSE Mini-Mental State Examination, ROS Religious Order Study, SD standard deviation
  3. aPercentage of those subjects with relevant information available