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Table 2 Correlations between the products of APP processing in FAD mutation carriers

From: The effects of different familial Alzheimer’s disease mutations on APP processing in vivo

  CSF biomarker sAPPα sAPPβ 38 40 42
MC sAPPα   0.87 (<0.01) 0.2 (0.4) 0.09 (0.7) -0.2 (0.4)
sAPPβ 0.87 (<0.01)   0.2 (0.3) 0.1 (0.6) -0.2 (0.5)
38 0.2 (0.4) 0.2 (0.3)   0.93 (<0.0001) 0.44 (0.06)
40 0.09 (0.7) 0.1 (0.6) 0.93 (<0.0001)   0.6 (0.01)
42 -0.2 (0.4) -0.2 (0.5) 0.44 (0.06) 0.6 (0.01)  
APPswe sAPPα    0.2 (0.6) 0.2 (0.7) -0.03 (0.9)
sAPPβ n.a. n.a. n.a. n.a. n.a.
38 0.2 (0.6)    0.9 (<0.001) 0.7 (0.06)
40 0.2 (0.7)   0.9 (<0.001)   0.8 (0.01)
42 -0.03 (0.9)   0.7 (0.06) 0.8 (0.01)  
PSEN1 sAPPα   0.66 (0.18) 0.20 (0.7) 0.20 (0.7) 0.086 (0.9)
sAPPβ 0.66 (0.18)   0.60 (0.2) 0.60 (0.2) 0.54 (0.3)
38 0.20 (0.7) 0.60 (0.2)   1 (<0.01) 0.83 (0.06)
40 0.20 (0.7) 0.60 (0.2) 1 (<0.01)   0.83 (0.06)
42 0.086 (0.9) 0.54 (0.3) 0.83 (0.06) 0.83 (0.06)  
NC sAPPα   0.64 (<0.01) 0.71 (<0.01) 0.72 (<0.01) 0.65 (<0.01)
sAPPβ 0.64 (<0.01)   0.28 (0.3) 0.33 (0.2) 0.29 (0.3)
38 0.71 (<0.01) 0.28 (0.3)   0.98 (<0.0001) 0.95 (<0.0001)
40 0.72 (<0.01) 0.33 (0.2) 0.98 (<0.0001)   0.98 (<0.0001)
42 0.65 (<0.01) 0.29 (0.3) 0.95 (<0.0001) 0.98 (<0.0001)  
  1. Correlations between the products of APP processing in the mutation carrier group as a whole (MC), carriers of the APPswe and PSEN1 mutations separately and in the nonmutation carriers (NC)
  2. Numbers represent Pearson/Spearman correlation coefficients (p values) (significant correlations in italics)
  3. APP amyloid precursor protein, FAD familial Alzheimer’s disease, amyloid beta, MC mutation carriers, NC noncarriers