Fig. 3
From: Tau passive immunization inhibits not only tau but also Aβ pathology
Immunization with tau antibodies 43D and 77E9 improves spatial memory beyond the period of immunization in 3×Tg-AD mice. Novel object location test was carried out 100 days after the last injection (see Fig. 1). a The percentage of time spent exploring two identical objects during sample phase (two-way ANOVA, F = 0.21, dfd = 56, p = 0.6484). b Discrimination index (time exploring object at novel location/time exploring object novel and familiar locations) × 100% in test phase (one-way ANOVA, F = 2.836, p = 0.0357; Bonferroni multiple comparisons test, WT-IgG vs. 3×Tg-IgG, p < 0.05; 3×Tg-IgG vs. 3×Tg-43D, p < 0.05). n = 6 and n = 5 for WT mice treated with IgG or 43D + 77E9, respectively; n = 6 for 3×Tg-AD mice treated with 43D, 77E9, or 43D + 77E9; and n = 8 for 3×Tg-AD mice treated with IgG. Data are reported as mean ± SEM. *p < 0.05 by one-way ANOVA followed by a Bonferroni post hoc test. ANOVA Analysis of variance, IgG Immunoglobulin G, 3×Tg Triple-transgenic, WT Wild type