Fig. 2

The effect of LW-AFC on the cognitive deterioration of APP/PS1 mice. Shown are: a the total distance in a spontaneous locomotor activity test; b the preferential index (time on novel object C/( time on novel object C + time on sample object A) × 100% ) in a novel object recognition test; the escape latency of c1 learning task and c2 probe trial, c3 number of times that the mice crossed the removed platform, and c4 swimming time in the target quadrant in the Morris water maze test; The d1 number of errors, d2 training time, and d3 memory retention in the step-down test; and the successful avoidance times during e1 training and e2 testing phases in the shuttle-box test. The values are mean ± SEM; n = 11–15. *P < 0.05, ***P < 0.001, versus the wild-type (WT) mouse group by unpaired Student's t test; ^# P < 0.05, ^## P < 0.01, ^### P < 0.001, versus the APP/PS1 (Tgs) mouse group by one-way ANOVA analysis followed by Dunnett’s post hoc test and two-way repeated-measures analysis of variance with Tukey multiple comparisons test