Fig. 1

Condensed representation, as a 2D scatter plot, of the CSF biomarker values of the study participants. The ensemble of trivariate measurements of CSF Aβ₄₂, p-Tau and t-Tau for all participants was analysed via NNMF and approximated by means of a bivariate data swarm that conveniently represents the total variation in the original data. Labels indicate the different groups and lend semantics to the plot. MCI _Non+ MCI without positive CSF biomarkers, MCI _Aβ+ MCI with positive Aβ₄₂ and negative or borderline p-Tau and t-Tau, MCI _Aβ+T+ MCI with positive Aβ₄₂ and positive t-Tau or p-Tau, MCI _All+ MCI with Aβ₄₂ and both t-Tau and p-Tau positive, MCI _T+ MCI with negative or borderline Aβ₄₂ and at least p-Tau or t-Tau positive