Memantine | No memantine | All | |||||
---|---|---|---|---|---|---|---|
Placebo | Galantamine | Placebo | Galantamine | Memantine | No memantine | p value | |
N | 245 | 251 | 776 | 773 | 496 | 1549 | |
Sex | |||||||
Women (%) | 60.4 | 67.3 | 65.2 | 64.9 | 63.9 | 65.1 | 0.7976χ |
Age (years) | |||||||
Mean (SD) | 74.2 (8.7) | 73.8 (8.8) | 72.8 (8.6) | 72.7 (8.9) | 74.0 (8.76) | 72.8 (8.76) | 0.008t |
MMSE | |||||||
Mean (SD) | 18.4 (4.2) | 18.0 (4.1) | 19.1 (4.0) | 19.4 (4.1) | 18.2 (4.16) | 19.2 (4.02) | 0.0001t |
DAD | |||||||
Mean (SD) | 59.0 (23.3) | 57.0 (23.7) | 61.5 (20.3) | 63.4 (20.7) | 58.0 (23.49) | 62.5 (20.52) | 0.0001t |
AD duration (years) | |||||||
Mean (SD) | 0.8 (1.3) | 1.1 (1.7) | 0.8 (1.7) | 0.7 (1.3) | 0.95 (1.50) | 0.75 (1.57) | 0.0127t |
Prior therapy | |||||||
Cholinomimetic use (%) | 23.3 | 23.5 | 16.0 | 13.3 | 23.4 | 14.7 | 0.0001χ |
Nursing home placement | |||||||
N | 116 | 101 | 312 | 305 | 217 | 617 | |
Cases, n (%) | 10 (8.6) | 3 (3.0) | 14 (4.5) | 13 (4.3) | 13 (6.0) | 27 (4.4) | 0.3507χ |