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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 7

Effects of Aβ1–42, melatonin, and Aβ1–42 plus melatonin on cell viability in hippocampal neurons. a Dose-dependent effect of Aβ1–42 on cell viability. *p < 0.05 and **p < 0.01 compared with control cells; ## p < 0.01 compared with 25 nM Aβ1–42-treated cells; ^ p < 0.05 and ^^ p < 0.01 compared with 50 nM Aβ1–42-treated cells. b Dose-dependent effect of melatonin on cell viability. **p < 0.01 compared with control cells; ## p < 0.01 compared with 5 μM melatonin-treated cells; ^^ p < 0.01 compared with 10 μM melatonin-treated cells; @ p < 0.05 compared with 50 μM melatonin-treated cells. c Effect of 50 μM melatonin on cell viability of 100 nM Aβ1–42-treated hippocampal neurons. **p < 0.01 compared with control cells; ## p < 0.01 compared with Aβ1–42-treated cells; ^^ p < 0.01 compared with melatonin-treated cells. Ctrl control cells, Aβ Aβ1–42-treated cells, Mel melatonin-treated cells, Aβ + Mel Aβ1–42 and melatonin-treated cells

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Alzheimer's Research & Therapy

ISSN: 1758-9193