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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 4

Melatonin restored the dendritic spine number and synaptic density in Aβ1–42-injected rats. a Representative images of Golgi-Cox staining of dendritic spines in the dentate gyrus (DG) and the CA1 and CA3 regions of the hippocampus. b Statistical analysis of the average number of Golgi-Cox stained dendritic spines in the DG and the CA1 and CA3 regions. c Representative images of immunofluorescent staining for SNAP25 in the DG and the CA1 and CA3 regions of the hippocampus. d Statistical analysis of immunofluorescent staining for SNAP25. e Representative images of immunofluorescent staining for synaptophysin in the DG and the CA1 and CA3 regions of the hippocampus. f Statistical analysis of immunofluorescent staining for synaptophysin. Scale bar = 100 μm. *p < 0.05 and **p < 0.01 compared with sham-operated rats; # p < 0.05 and ## p < 0.01 compared with Aβ1–42-injected rats. Ctrl control group, Aβ Aβ1–42-injected group, Mel melatonin-injected group, Aβ + Mel dual Aβ1–42 and melatonin-injected group, SYTO synaptophysin, DAPI 4′,6-diamidino-2-phenylindole

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Alzheimer's Research & Therapy

ISSN: 1758-9193