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Table 1 Normalized AUC and relative percentage change versus DMSO for each peptide measured by mass spectrometry

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

 5–37 5–38 5–40 1–33 1–34 1–37 1–38 1–39 1–40 1–42
DMSO 0.4 1 3 1.8 0.4 5.8 11.9 3.5 38.9 1.9
FRM-36143 1.9 1.5 1.2 2.9 0.5 23.6 15 1.6 10 0.4
Percentage change (vs. DMSO) 475 150 40 161 125 407 126 46 26 21