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Table 1 Normalized AUC and relative percentage change versus DMSO for each peptide measured by mass spectrometry

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

 

5–37

5–38

5–40

1–33

1–34

1–37

1–38

1–39

1–40

1–42

DMSO

0.4

1

3

1.8

0.4

5.8

11.9

3.5

38.9

1.9

FRM-36143

1.9

1.5

1.2

2.9

0.5

23.6

15

1.6

10

0.4

Percentage change (vs. DMSO)

475

150

40

161

125

407

126

46

26

21