From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease
Aβ5–37
Aβ5–38
Aβ5–40
Aβ1–33
Aβ1–34
Aβ1–37
Aβ1–38
Aβ1–39
Aβ1–40
Aβ1–42
DMSO
0.4
1
3
1.8
5.8
11.9
3.5
38.9
1.9
FRM-36143
1.5
1.2
2.9
0.5
23.6
15
1.6
10
Percentage change (vs. DMSO)
475
150
40
161
125
407
126
46
26
21