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Table 2 Location and peak significance of grey matter volume loss using VBM-DARTEL

From: Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease

  Voxel level (P FWE) Extent (k) T, Z scores MNI coordinates (x, y, z) (mm) Region
Pro-DLB vs. control subjects <0.001 2361 7.1, 6.0 11, 57, 18 Right superior frontal
    7.1, 6.0 9, 50, 13 Right paracingulate
  <0.001 461 6.8, 5.8 −38, 11, 13 Left insula
  0.001 1321 6.4, 5.5 −29, 24, −6 Left insula
  0.001 340 6.1, 5.3 −8, −63, 45 Left precuneus
  0.002 53 5.9, 5.2 14, −43, 43 Right precuneus
  0.002 359 5.9, 5.2 30, 29, −3 Right inferior frontal
  0.006 137 5.6, 5.0 39, 5, 7 Right insula
  0.009 35 5.5, 4.9 5, 68, −3 Right medial frontal
  0.016 25 5.3, 4.8 −14, 60, 7 Left medial frontal
  0.017 15 5.3, 4.8 −29, 29, 40 Left middle frontal
  0.018 31 5.3, 4.7 26, 56, −11 Right superior frontal
  0.033 12 5.1, 4.6 −14, 47, 0 Left anterior cingulate
Pro-AD vs. control subjects <0.001 24,640 9.8, 7.4 12, 59, −15 Right medial frontal
    8.6, 6.8 50, 47, −3 Right inferior frontal
    8.0, 6.5 −30, −19, −18 Left hippocampus
    7.4, 6.2 42, 54, −14 Right middle frontal
    7.3, 6.1 −44, 26, −5 Left inferior frontal
    7.3, 6.1 −12, 62, −3 Left medial frontal
    7.3, 6.1 −9, 69, −-9 Left superior frontal
  <0.001 1144 6.7, 5.7 35, 21, −42 Right temporal pole
    6.1, 5.3 39, 8, −33 Right superior temporal
  0.001 1881 6.3, 5.5 12, −39, 42 Right posterior cingulate
    6.1, 5.3 −8, −39, 40 Left posterior cingulate
  0.002 176 6.0, 5.2 33, −81, −53 Right posterior cerebellum
  0.003 67 5.9, 5.2 11, −9, 39 Right mid-cingulate
  0.004 392 5.8, 5.1 15, 24, 61 Right superior frontal
  0.004 94 5.8, 5.1 −47, −84, −9 Left inferior occipital
  0.004 145 5.8, 5.1 −5, −48, −27 Left anterior cerebellum
  0.005 527 5.7, 5.0 −33, −70, 39 Left precuneus
  0.007 178 5.6, 5.0 −11, 15, 39 Left mid-cingulate
  0.008 113 5.5, 4.9 48, −76, 24 Right middle temporal
  0.011 12 5.4, 4.8 18, −72, 56 Right superior parietal
  0.011 137 5.4, 4.8 29, −12, −14 Right hippocampus
  0.012 42 5.4, 4.8 −60, 2, −27 Left middle temporal
Pro-AD vs. pro-DLB 0.006 79 5.6, 4.9 20, −42, 60 Right superior parietal
Pro-DLB (hallucinators vs. non-hallucinators) 0.002a 82 3.1, 2.8 −5, −84, 18 Left cuneus BA17
  1. Abbreviations: BA Brodmann area, FWE family-wise error, MNI Montreal Neurological Institute, pro-AD prodromal Alzheimer’s disease, pro-DLB prodromal dementia with Lewy bodies, VBM-DARTEL voxel-based morphometry with diffeomorphic anatomical registration through exponentiated lie algebra
  2. Table depicts voxel-level significance (P FWE), spatial extent (k), T and Z scores, MNI coordinates and anatomical region
  3. aUncorrected P value