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Table 4 Significant changes of relative perfusion according to the level of cognitive impairment

From: Brain perfusion in dementia with Lewy bodies and Alzheimer’s disease: an arterial spin labeling MRI study on prodromal and mild dementia stages

Contrast

Region

Laterality

Extent

Coordinates (x,y,z)

Mild DLB < pro DLB

Caudate nucleus

L

4968

–12

6

12

 

Inferior frontal

L

2064

–32

14

24

 

Middle temporal

L

1320

–58

–10

–18

 

Anterior insula

L

1144

–28

24

4

 

Caudate nucleus

R

936

10

10

4

 

Middle cingulum

R

880

10

4

42

 

Anterior cingulum

R

704

16

34

20

 

Middle temporal

R

456

60

–12

–16

 

Middle temporal

L

384

–56

–56

8

Pro DLB < mild DLB

Precuneus

L

744

–4

–60

58

Mild AD < pro AD

Inferior parietal

L

1544

–60

–46

42

 

Precuneus

R

344

14

–60

28

Pro AD < mild AD

Cuneus

L

496

16

–102

12

 

Inferior frontal

R

432

34

38

0

  1. Extent is expressed in mm3. Coordinates are in the Montreal National Institute space. Sensitivity and specificity are percentages, relative to DLB identification except for comparison between AD and HC AD Alzheimer’s disease, DLB dementia with Lewy bodies, HC healthy (elderly) controls, L left hemisphere, R right hemisphere
  2. * p FWE<0.05