Fig. 2
From: CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease
CRTC1 mRNA expression is decreased in human hippocampus in Alzheimer’s disease (AD). a The graph shows a significant 1.54-fold decrease in CRTC1 mRNA levels in AD hippocampal samples compared to control hippocampal samples. b CRTC1 mRNA expression decreases across AD stages, as shown when CRTC1 expression levels are sorted based on ABC score. Boxes represent percentage of CRTC1 expression relative to the geometric mean of GAPDH and ACTB housekeeping genes expression. Bars represent the standard error of the mean. *p-value < 0.05; ** p-value < 0.005. c Two different CRTC1 transcript variants are shown. CRTC1 variant 1 has 14 exons and CRTC1 variant 3 shares all the exons of variant 1 plus an additional exon 3. Black boxes represent exons, arrows represent transcription start sites and white boxes denote CpG islands. CpG cytosine-phosphate-guanine