Alzheimer's Research & Therapy

Table 3 Correlation analyses of CSF sTREM2 in relation to other AD CSF biomarkers in the Norwegian and Swedish cohorts

From: Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

	sTREM2 correlation
	Norwegian cohort					Swedish cohort
	All (n = 100)	AD (n = 29)	MCI (n = 21)	Control (n = 50)	Aβ42 > 700 (n = 46)	All (n = 50)	AD (n = 25)	Control (n = 25)
T-tau	r = 0.28	r = 0.22	r = –0.06	r = 0.57	r = 0.63	r = 0.17	r = 0.05	r = 0.29
T-tau	p = 0.005	p = 0.25	p = 0.81	p < 0.001	p < 0.001	p = 0.24	p = 0.82	p = 0.16
P-tau	r = 0.33	r = –0.04	r = 0.27	r = 0.63	r = 0.69	r = 0.17	r = 0.00	r = 0.44
P-tau	p = 0.001	p = 0.85	p = 0.24	p < 0.001	p < 0.001	p = 0.23	p = 0.99	p = 0.02
Aβ42	r = 0.04	r = –0.05	r = 0.07	r = 0.35	r = 0.44	r = 0.09	r = 0.35	r = 0.06
Aβ42	p = 0.67	p = 0.79	p = 0.77	p = 0.01	p = 0.002	p = 0.55	p = 0.09	p = 0.79
				n = 32	n = 31
Aβ38 (MSD)				r = 0.49	r = 0.51
Aβ38 (MSD)				p = 0.005	p = 0.004
Aβ40 (MSD)				r = 0.51	r = 0.53
Aβ40 (MSD)				p = 0.003	p = 0.002
Aβ42 (MSD)				r = 0.37	r = 0.40
Aβ42 (MSD)				p = 0.04	p = 0.03

Correlations between CSF sTREM2 levels and levels of T-tau, P-tau, Aβ42, Aβ38 MSD, Aβ40 MSD and Aβ42 MSD in AD, MCI and control patients of the two cohorts. Correlations are presented as Spearman rho (r) since most data not were normally distributed
Aβ42 amyloid beta 1–42, AD Alzheimer’s disease, CSF cerebrospinal fluid, MCI mild cognitive impairment, MSD Meso Scale Discovery, P-tau phosphorylated Tau, sTREM2 soluble triggering receptor expressed on myeloid cells 2, T-tau total Tau

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