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Table 3 Correlation analyses of CSF sTREM2 in relation to other AD CSF biomarkers in the Norwegian and Swedish cohorts

From: Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

  sTREM2 correlation
  Norwegian cohort Swedish cohort
  All (n = 100) AD (n = 29) MCI (n = 21) Control (n = 50) Aβ42 > 700 (n = 46) All (n = 50) AD (n = 25) Control (n = 25)
T-tau r = 0.28 r = 0.22 r = –0.06 r = 0.57 r = 0.63 r = 0.17 r = 0.05 r = 0.29
p = 0.005 p = 0.25 p = 0.81 p < 0.001 p < 0.001 p = 0.24 p = 0.82 p = 0.16
P-tau r = 0.33 r = –0.04 r = 0.27 r = 0.63 r = 0.69 r = 0.17 r = 0.00 r = 0.44
p = 0.001 p = 0.85 p = 0.24 p < 0.001 p < 0.001 p = 0.23 p = 0.99 p = 0.02
Aβ42 r = 0.04 r = –0.05 r = 0.07 r = 0.35 r = 0.44 r = 0.09 r = 0.35 r = 0.06
p = 0.67 p = 0.79 p = 0.77 p = 0.01 p = 0.002 p = 0.55 p = 0.09 p = 0.79
     n = 32 n = 31    
Aβ38 (MSD)     r = 0.49 r = 0.51    
    p = 0.005 p = 0.004    
Aβ40 (MSD)     r = 0.51 r = 0.53    
    p = 0.003 p = 0.002    
Aβ42 (MSD)     r = 0.37 r = 0.40    
    p = 0.04 p = 0.03    
  1. Correlations between CSF sTREM2 levels and levels of T-tau, P-tau, Aβ42, Aβ38 MSD, Aβ40 MSD and Aβ42 MSD in AD, MCI and control patients of the two cohorts. Correlations are presented as Spearman rho (r) since most data not were normally distributed
  2. Aβ42 amyloid beta 1–42, AD Alzheimer’s disease, CSF cerebrospinal fluid, MCI mild cognitive impairment, MSD Meso Scale Discovery, P-tau phosphorylated Tau, sTREM2 soluble triggering receptor expressed on myeloid cells 2, T-tau total Tau