From: Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials
Sensitivity | Specificity | PPV | NPV | |
---|---|---|---|---|
LM-II score (A4 Trial) (10,741 normal cognition; 6814 AD dementia) | ||||
Cutoff score = 6 | 89.0 | 91.1 | 86.4 | 92.9 |
LM-II score (BAN2401 Trial) | ||||
50–64 years (2315 normal cognition; 995 AD dementia) | ||||
Cutoff score = 15 | 99.4 | 27.8 | 37.2 | 99.1 |
65–69 years (2092 normal cognition; 722 AD dementia) | ||||
Cutoff score = 12 | 98.5 | 52.0 | 41.4 | 99.0 |
70–74 years (2083 normal cognition; 1082 AD dementia) | ||||
Cutoff score = 11 | 97.3 | 57.3 | 54.2 | 97.6 |
75–79 years (1824 normal cognition; 1562 AD dementia) | ||||
Cutoff score = 9 | 96.2 | 70.0 | 73.3 | 95.6 |
80–90 years (2212 normal cognition; 2263 AD dementia) | ||||
Cutoff score = 7 | 93.9 | 80.7 | 83.3 | 92.9 |
LM-II score (ADNI 2) | ||||
16+ years of education (6583 normal cognition; 3118 AD dementia) | ||||
Cutoff score = 8 | 92.4 | 90.9 | 82.8 | 96.2 |
8–15 years of education (4061 normal cognition; 3518 AD dementia) | ||||
Cutoff score = 4 | 84.4 | 94.6 | 93.1 | 87.5 |
0–7 years of education (51 normal cognition; 143 AD dementia) | ||||
Cutoff score = 2 | 77.8 | 88.2 | 94.9 | 58.4 |