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Table 2 AUC values for MMSE and LM-II cutoffs used in AD clinical trials and diagnostic studies in NACC subjects

From: Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials

  Normal cognition vs. MCI Normal cognition vs. AD dementia MCI vs. AD dementia
MMSE scores    
 MCI cutoff score ≤26 0.63
 AD dementia cutoff score ≤24 0.85 0.80
LM-II score (A4 Trial)    
 Cutoff score <6 0.67 0.92 0.74
LM-II score (BAN2401)    
 50–64 years old    
  Cutoff score ≤15 0.61 0.64 0.53
 65–69 years old    
  Cutoff score ≤12 0.68 0.76 0.58
 70–74 years old    
  Cutoff score ≤11 0.71 0.78 0.57
 75–79 years old    
  Cutoff score ≤9 0.72 0.84 0.62
 80–90 years old    
  Cutoff score ≤7 0.72 0.88 0.67
LM-II score (for early MCI in ADNI 2)    
 16+ years of education    
  Cutoff score ≤11 0.72
 8–15 years of education   
  Cutoff score ≤9 0.70
 0–7 years of education   
  Cutoff score ≤6 0.69
LM-II score (for AD dementia in ADNI 2)    
 16+ years of education    
  Cutoff score ≤8 0.90 0.67
 8–15 years of education    
  Cutoff score ≤4 0.92 0.76
 0–7 years of education    
  Cutoff score ≤2 0.87 0.76
  1. Abbreviations: NACC National Alzheimer’s Coordinating Center, MMSE Mini Mental State Examination, LM-II Wechsler Memory Scale Logical Memory-II, MCI mild cognitive impairment, ADNI 2 Alzheimer’s Disease Neuroimaging Initiative 2, AUC area under the receiver operating characteristic curve
  2. Cutoffs were chosen on the basis of those used in AD clinical trials and diagnostic studies: “Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease” (6–18 = asymptomatic AD); “A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose-Regimen-find Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects with Early Alzheimer’s Disease” (50–64 years: ≤15; 65–69 years: ≤12; 70–74 years: ≤11; 75–79 years: ≤9; 80–90 years ≤7; and ADNI 2 (16 years of education: normal ≥9; early MCI 9–11; AD ≤8; 8–15 years of education: normal ≥5; early MCI 5–9; AD ≤4; 0–7 years of education: normal ≥3; early MCI 3–6; AD ≤2)