Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials

Table 2 AUC values for MMSE and LM-II cutoffs used in AD clinical trials and diagnostic studies in NACC subjects

	Normal cognition vs. MCI	Normal cognition vs. AD dementia	MCI vs. AD dementia
MMSE scores
MCI cutoff score ≤26	0.63	–	–
AD dementia cutoff score ≤24	–	0.85	0.80
LM-II score (A4 Trial)
Cutoff score <6	0.67	0.92	0.74
LM-II score (BAN2401)
50–64 years old
Cutoff score ≤15	0.61	0.64	0.53
65–69 years old
Cutoff score ≤12	0.68	0.76	0.58
70–74 years old
Cutoff score ≤11	0.71	0.78	0.57
75–79 years old
Cutoff score ≤9	0.72	0.84	0.62
80–90 years old
Cutoff score ≤7	0.72	0.88	0.67
LM-II score (for early MCI in ADNI 2)
16+ years of education
Cutoff score ≤11	0.72	–	–
8–15 years of education			–
Cutoff score ≤9	0.70	–	–
0–7 years of education			–
Cutoff score ≤6	0.69	–	–
LM-II score (for AD dementia in ADNI 2)
16+ years of education
Cutoff score ≤8	–	0.90	0.67
8–15 years of education
Cutoff score ≤4	–	0.92	0.76
0–7 years of education
Cutoff score ≤2	–	0.87	0.76

Abbreviations: NACC National Alzheimer’s Coordinating Center, MMSE Mini Mental State Examination, LM-II Wechsler Memory Scale Logical Memory-II, MCI mild cognitive impairment, ADNI 2 Alzheimer’s Disease Neuroimaging Initiative 2, AUC area under the receiver operating characteristic curve
Cutoffs were chosen on the basis of those used in AD clinical trials and diagnostic studies: “Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease” (6–18 = asymptomatic AD); “A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose-Regimen-find Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects with Early Alzheimer’s Disease” (50–64 years: ≤15; 65–69 years: ≤12; 70–74 years: ≤11; 75–79 years: ≤9; 80–90 years ≤7; and ADNI 2 (16 years of education: normal ≥9; early MCI 9–11; AD ≤8; 8–15 years of education: normal ≥5; early MCI 5–9; AD ≤4; 0–7 years of education: normal ≥3; early MCI 3–6; AD ≤2)

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