Skip to main content

Table 1 NACC sample characteristics

From: Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials

 

Normal cognition

MCI

AD dementia

P value

Number of subjects

10,741

5883

6814

Age, yr, mean (SD)

71.92 (9.40)

73.87 (8.93)

75.28 (9.28)

<0.001

Education,a yr, mean (SD)

15.74 (2.86)

15.21 (3.21)

14.53 (3.30)

<0.001

Female sex, n (%)

7047 (65.6)

2907 (49.4)

3689 (54.1)

<0.001

White race,a n (%)

8713 (81.3)

4682 (79.8)

5639 (82.8)

<0.01

Global CDR, mean (SD)

0.05 (0.15)

0.46 (0.17)

1.02 (0.57)

<0.001

MMSE, mean (SD)

28.88 (1.41)

27.11 (2.43)

20.92 (5.50)

<0.001

Logical Memory-II raw score, mean (SD)

12.17 (4.13)

6.92 (4.64)

1.82 (2.88)

<0.001

  1. Abbreviations: NACC National Alzheimer’s Coordinating Center, CDR Clinical Dementia Rating, MMSE Mini Mental State Examination, MCI mild cognitive impairment, AD Alzheimer’s disease, SD standard deviation
  2. Post hoc analyses showed significant differences across all three groups
  3. aDue to missing data, sample size for education is reduced to 10,695 for normal cognition, 5863 MCI, and 6779 for AD dementia and sample size for race is 10,721 normal cognition, 5869 MCI, and 6807 AD