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Table 1 NACC sample characteristics

From: Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials

  Normal cognition MCI AD dementia P value
Number of subjects 10,741 5883 6814
Age, yr, mean (SD) 71.92 (9.40) 73.87 (8.93) 75.28 (9.28) <0.001
Education,a yr, mean (SD) 15.74 (2.86) 15.21 (3.21) 14.53 (3.30) <0.001
Female sex, n (%) 7047 (65.6) 2907 (49.4) 3689 (54.1) <0.001
White race,a n (%) 8713 (81.3) 4682 (79.8) 5639 (82.8) <0.01
Global CDR, mean (SD) 0.05 (0.15) 0.46 (0.17) 1.02 (0.57) <0.001
MMSE, mean (SD) 28.88 (1.41) 27.11 (2.43) 20.92 (5.50) <0.001
Logical Memory-II raw score, mean (SD) 12.17 (4.13) 6.92 (4.64) 1.82 (2.88) <0.001
  1. Abbreviations: NACC National Alzheimer’s Coordinating Center, CDR Clinical Dementia Rating, MMSE Mini Mental State Examination, MCI mild cognitive impairment, AD Alzheimer’s disease, SD standard deviation
  2. Post hoc analyses showed significant differences across all three groups
  3. aDue to missing data, sample size for education is reduced to 10,695 for normal cognition, 5863 MCI, and 6779 for AD dementia and sample size for race is 10,721 normal cognition, 5869 MCI, and 6807 AD