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Table 6 Signal-to-noise ratio for change in ADAS-Cog variants over 12 months in mild AD cohorts

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

  ADAS-Cog 3 ADAS-Cog 5 ADAS-Cog 11 ADAS-Cog 13
  SNR 95 % CI SNR 95 % CI SNR 95 % CI SNR 95 % CI
Mild AD 0.81 0.43–1.09 0.93 0.52–1.22 0.87 0.46–1.13 0.98 0.58–1.26
t-Tau/Aβ 0.83 0.41–1.10 0.95 0.53–1.23 0.86 0.46–1.12 0.96 0.55–1.24
0.86 0.45–1.14 0.98 0.52–1.27 0.88 0.46–1.14 0.99 0.56–1.26
ApoE+ 0.87 0.37–1.20 1.01 0.50–1.35 1.05 0.56–1.36 1.16 0.66–1.50
t-Tau 0.89 0.38–1.21 1.13 0.55–1.46 0.86 0.39–1.16 1.04 0.49–1.35
p-Tau 0.82 0.42–1.10 0.96 0.50–1.24 0.87 0.46–1.16 0.99 0.58–1.27
  1. amyloid β; AD Alzheimer’s disease, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CI confidence interval, MMSE Mini Mental State Examination, SNR signal-to-noise ratio
  2. SNR estimates corrected for covariates, reported for an ApoE4-positive 75-year-old woman, baseline score corresponding to ADAS-Cog 11 of 18, baseline MMSE score of 23. CIs were obtained via bootstrapping