Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

Table 6 Signal-to-noise ratio for change in ADAS-Cog variants over 12 months in mild AD cohorts

	ADAS-Cog 3		ADAS-Cog 5		ADAS-Cog 11		ADAS-Cog 13
	SNR	95 % CI	SNR	95 % CI	SNR	95 % CI	SNR	95 % CI
Mild AD	0.81	0.43–1.09	0.93	0.52–1.22	0.87	0.46–1.13	0.98	0.58–1.26
t-Tau/Aβ	0.83	0.41–1.10	0.95	0.53–1.23	0.86	0.46–1.12	0.96	0.55–1.24
Aβ	0.86	0.45–1.14	0.98	0.52–1.27	0.88	0.46–1.14	0.99	0.56–1.26
ApoE+	0.87	0.37–1.20	1.01	0.50–1.35	1.05	0.56–1.36	1.16	0.66–1.50
t-Tau	0.89	0.38–1.21	1.13	0.55–1.46	0.86	0.39–1.16	1.04	0.49–1.35
p-Tau	0.82	0.42–1.10	0.96	0.50–1.24	0.87	0.46–1.16	0.99	0.58–1.27

Aβ amyloid β; AD Alzheimer’s disease, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CI confidence interval, MMSE Mini Mental State Examination, SNR signal-to-noise ratio
SNR estimates corrected for covariates, reported for an ApoE4-positive 75-year-old woman, baseline score corresponding to ADAS-Cog 11 of 18, baseline MMSE score of 23. CIs were obtained via bootstrapping

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