Increased CSF tau level is correlated with decreased lamina cribrosa thickness

Table 3 Factors associated with the lamina cribrosa thickness

	Univariate analysis			Multivariate analysis			VIF
	β	95 % CI	P value	β	95 % CI	P value	VIF
Gender, male	5.769	–15.954, 27.493	0.595
Age, per 1 year older	–1.103	–2.371, 0.165	0.087	–0.572	–1.746, 0.601	0.330	1.086
Aβ_1–42, per 1 pg/ml larger	–0.024	–0.100, 0.052	0.521
T-tau, per 1 pg/ml larger	–0.326	–0.543, –0.108	0.004	–0.362	–0.709, –0.016	0.041	2.843
P-tau_181P , per 1 pg/ml larger	–0.582	–1.095, –0.069	0.027	0.166	–0.627, 0.958	0.674	2.882
CSF pressure, per 1 mmHg higher	0.593	–3.526, 4.712	0.773
Total MMSE score, per 1 point higher	0.894	–1.108, 2.896	0.373
IOP, per 1 mmHg higher	0.294	–3.737, 4.325	0.884
Spherical error, per 1 D larger	0.024	–5.983, 6.032	0.994
Global RNFL thickness, per 1 μm thicker	0.930	–0.025, 1.886	0.056	0.845	–0.020, 1.709	0.055	1.113
Central corneal thickness, per 1 μm thicker	0.349	0.032, 0.666	0.032	0.216	–0.091, 0.524	0.163	1.145
Axial length, per 1 mm longer	3.516	–7.861, 14.893	0.536

Statistically significant values are shown in bold
Aβ _1–42 amyloid β_1–42, CI confidence interval, CSF cerebrospinal fluid, IOP intraocular pressure, MMSE Mini-Mental Status Examination, P-tau _181P phosphorylated tau_181P, RNFL retinal nerve fiber layer, T-tau total tau, VIF variance inflation factor

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