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Table 3 Attention test (speed of response & movement)

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Reaction Time (RTI)
Drug Name of task Mean ± SEM p1 value 95 % CI-D (Lower, Upper) Cohen’s d for p1 Value p2 Value 95 % CI-D (Lower, Upper) Cohen’s d for p2 Value
Baseline After 7 Days
OME RTI FC movement time 440.800 ± 70.397 550.600 ±33.557 0.021* −215.510, -4.090 1.567ǂ 0.006** 43.597, 311.193 1.313ǂ
RTI FC reaction time 401.600 ± 24.419 401.700 ±47.429 0.499 −84.483, 84.283 0.002 0.228 −160.450,75.203 0.358
LAN RTI FC movement time 429.600 ± 42.988 494.200 ±62.281 0.033* −134.633, 5.433 1.391ǂ 0.080 −52.458, 294.283 0.691
RTI FC reaction time 411.500 ± 34.816 427.100 ±19.626 0.337 −96.876, 65.676 0.289 0.319 −92.282, 58.072 0.225
RAB RTI FC movement time 441.400 ± 52.311 541.700 ±56.709 0.030* −206.318, 5.718 1.427ǂ 0.023* 3.586, 332.896 1.012ǂ
RTI FC reaction time 350.900 ± 18.929 355.500 ±24.407 0.389 −40.606, 31.406 0.193 0.017* −169.820, -7.443 1.081ǂ
PAN RTI FC movement time 431.400 ± 31.271 558.900 ±40.799 0.008** −226.400, -28.600 1.944ǂ 0.007** 43.011, 327.913 1.289ǂ
RTI FC reaction time 438.500 ± 29.655 459.000 ±28.355 0.275 −95.345, 54.345 0.413 0.361 −71.730, 101.519 0.170
ESO RTI FC movement time 10.200 ± 1.618 9.300 ± 2.357 0.248 −178.053, 93.053 0.473 0.187 −91.254, 230.490 0.428
RTI FC reaction time 2.400 ± 0.562 2.100 ± 0.674 0.297 −127.810, 77.610 0.369 0.303 −99.234, 165.251 0.247
CON RTI FC movement time 415.100 ± 52.731 371.300 ±54.126 0.182 −57.137, 140.737 N/A
RTI FC reaction time 466.600 ± 29.218 444.000 ±29.954 0.128 −19.658, 64.858 N/A
  1. Values are expressed as mean ± SEM (n=10), FC=Five-Choice, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. * and ** indicate statistically significant at alpha (<0.05) & (<0.01) respectively. ǂ indicates large effect size in Cohen’s d value