Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Sanjida Akter; Md. Rajib Hassan; Mohammad Shahriar; Nahia Akter; Md. Golam Abbas; Mohiuddin Ahmed Bhuiyan

doi:10.1186/s13195-015-0164-8

Alzheimer's Research & Therapy

Table 3 Attention test (speed of response & movement)

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Reaction Time (RTI)
Drug	Name of task	Mean ± SEM		p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
Drug	Name of task	Baseline	After 7 Days	p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
OME	RTI FC movement time	440.800 ± 70.397	550.600 ±33.557	0.021*	−215.510, -4.090	1.567^ǂ	0.006**	43.597, 311.193	1.313^ǂ
OME	RTI FC reaction time	401.600 ± 24.419	401.700 ±47.429	0.499	−84.483, 84.283	0.002	0.228	−160.450,75.203	0.358
LAN	RTI FC movement time	429.600 ± 42.988	494.200 ±62.281	0.033*	−134.633, 5.433	1.391^ǂ	0.080	−52.458, 294.283	0.691
LAN	RTI FC reaction time	411.500 ± 34.816	427.100 ±19.626	0.337	−96.876, 65.676	0.289	0.319	−92.282, 58.072	0.225
RAB	RTI FC movement time	441.400 ± 52.311	541.700 ±56.709	0.030*	−206.318, 5.718	1.427^ǂ	0.023*	3.586, 332.896	1.012^ǂ
RAB	RTI FC reaction time	350.900 ± 18.929	355.500 ±24.407	0.389	−40.606, 31.406	0.193	0.017*	−169.820, -7.443	1.081^ǂ
PAN	RTI FC movement time	431.400 ± 31.271	558.900 ±40.799	0.008**	−226.400, -28.600	1.944^ǂ	0.007**	43.011, 327.913	1.289^ǂ
PAN	RTI FC reaction time	438.500 ± 29.655	459.000 ±28.355	0.275	−95.345, 54.345	0.413	0.361	−71.730, 101.519	0.170
ESO	RTI FC movement time	10.200 ± 1.618	9.300 ± 2.357	0.248	−178.053, 93.053	0.473	0.187	−91.254, 230.490	0.428
ESO	RTI FC reaction time	2.400 ± 0.562	2.100 ± 0.674	0.297	−127.810, 77.610	0.369	0.303	−99.234, 165.251	0.247
CON	RTI FC movement time	415.100 ± 52.731	371.300 ±54.126	0.182	−57.137, 140.737	N/A
CON	RTI FC reaction time	466.600 ± 29.218	444.000 ±29.954	0.128	−19.658, 64.858	N/A

Values are expressed as mean ± SEM (n=10), FC=Five-Choice, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. * and ** indicate statistically significant at alpha (<0.05) & (<0.01) respectively. ^ǂ indicates large effect size in Cohen’s d value

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