Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Akter, Sanjida; Hassan, Md. Rajib; Shahriar, Mohammad; Akter, Nahia; Abbas, Md. Golam; Bhuiyan, Mohiuddin Ahmed

doi:10.1186/s13195-015-0164-8

Alzheimer's Research & Therapy

Table 2 Memory test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Paired Associates Learning (PAL)
Drug	Name of task	Mean ± SEM		p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
Drug	Name of task	Baseline	After 7 Days	p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
OME	PAL TE (adjusted)	5.300 ± 1.212	9.900 ± 2.331	0.013*	−8.521, -0.679	1.769^ǂ	0.207	−4.098, 9.498	0.393
OME	PAL TE(6 shapes, adjusted)	1.800 ± 0.800	3.700 ± 0.955	0.023*	−3.761, -0.039	1.540^ǂ	0.042*	−0.310, 4.510	0.863^ǂ
LAN	PAL TE(adjusted)	8.400 ± 1.973	14.400 ±6.143	0.151	−18.422, 6.422	0.729	0.142	−6.541, 20.941	0.519
LAN	PAL TE(6 shapes, adjusted)	1.600 ± 0.670	5.100 ± 1.696	0.012*	−6.445, -0.555	1.793^ǂ	0.034*	−0.305, 7.035	0.911^ǂ
RAB	PAL TE (adjusted)	8.300 ± 1.739	8.800 ± 2.886	0.448	−8.919, 7.919	0.089	0.333	−6.081, 9.281	0.206
RAB	PAL TE(6 shapes, adjusted)	1.400 ± 0.670	1.900 ± 1.048	0.361	−3.959, 2.595	0.243	0.404	−2.275, 2.875	0.115
PAN	PAL TE(adjusted)	4.000 ± 1.374	6.200 ± 1.988	0.046*	−4.851, 0.451	1.251^ǂ	0.371	−7.299, 5.299	0.157
PAN	PAL TE(6 shapes, adjusted)	1.500 ± 0.749	2.700 ± 1.334	0.180	−4.017, 1.617	0.643	0.233	−2.004, 4.204	0.351
ESO	PAL TE (adjusted)	10.200±1.618	9.300 ± 2.357	0.364	−4.767, 6.567	0.239	0.263	−4.739, 8.939	0.304
ESO	PAL TE(6 shapes, adjusted)	2.400 ± 0.562	2.100 ± 0.674	0.388	−2.013, 2.613	0.195	0.298	−1.447, 2.447	0.255
CON	PAL TE(adjusted)	8.300 ± 2.530	7.200 ± 2.245	0.242	−2.313, 4.513	N/A
CON	PAL TE(6 shapes, adjusted)	2.500 ± 1.138	1.600 ± 0.636	0.194	−1.348, 3.148	N/A

Values are expressed as mean ± SEM (n=10), TE=Total errors, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18.* indicates statistically significant at alpha (<0.05). ^ǂ indicates large effect size in Cohen’s d value

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ISSN: 1758-9193

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