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Table 2 Memory test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Paired Associates Learning (PAL)
Drug Name of task Mean ± SEM p1 value 95 % CI-D (Lower, Upper) Cohen’s d for p1 Value p2 Value 95 % CI-D (Lower, Upper) Cohen’s d for p2 Value
Baseline After 7 Days
OME PAL TE (adjusted) 5.300 ± 1.212 9.900 ± 2.331 0.013* −8.521, -0.679 1.769ǂ 0.207 −4.098, 9.498 0.393
PAL TE(6 shapes, adjusted) 1.800 ± 0.800 3.700 ± 0.955 0.023* −3.761, -0.039 1.540ǂ 0.042* −0.310, 4.510 0.863ǂ
LAN PAL TE(adjusted) 8.400 ± 1.973 14.400 ±6.143 0.151 −18.422, 6.422 0.729 0.142 −6.541, 20.941 0.519
PAL TE(6 shapes, adjusted) 1.600 ± 0.670 5.100 ± 1.696 0.012* −6.445, -0.555 1.793ǂ 0.034* −0.305, 7.035 0.911ǂ
RAB PAL TE (adjusted) 8.300 ± 1.739 8.800 ± 2.886 0.448 −8.919, 7.919 0.089 0.333 −6.081, 9.281 0.206
PAL TE(6 shapes, adjusted) 1.400 ± 0.670 1.900 ± 1.048 0.361 −3.959, 2.595 0.243 0.404 −2.275, 2.875 0.115
PAN PAL TE(adjusted) 4.000 ± 1.374 6.200 ± 1.988 0.046* −4.851, 0.451 1.251ǂ 0.371 −7.299, 5.299 0.157
PAL TE(6 shapes, adjusted) 1.500 ± 0.749 2.700 ± 1.334 0.180 −4.017, 1.617 0.643 0.233 −2.004, 4.204 0.351
ESO PAL TE (adjusted) 10.200±1.618 9.300 ± 2.357 0.364 −4.767, 6.567 0.239 0.263 −4.739, 8.939 0.304
PAL TE(6 shapes, adjusted) 2.400 ± 0.562 2.100 ± 0.674 0.388 −2.013, 2.613 0.195 0.298 −1.447, 2.447 0.255
CON PAL TE(adjusted) 8.300 ± 2.530 7.200 ± 2.245 0.242 −2.313, 4.513 N/A
PAL TE(6 shapes, adjusted) 2.500 ± 1.138 1.600 ± 0.636 0.194 −1.348, 3.148 N/A
  1. Values are expressed as mean ± SEM (n=10), TE=Total errors, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18.* indicates statistically significant at alpha (<0.05). ǂ indicates large effect size in Cohen’s d value