Fig. 3
From: APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
Full mass spectrum of 80 mg/kg γ-secretase modulation effect in dogs. Full mass spectra of APLP1 were acquired by hybrid immuno-affinity MALDI-TOF/TOF mass spectrometry. The spectra show the relative changes of the APLP1 peptides in cerebrospinal fluid collected from a dog a prior to dosing with 80 mg/kg of the γ-secretase modulator E2012 and subsequently b 4, c 8 and d 24 hours after dosing. APLP1 Amyloid-like protein 1