From: Diagnostic value of cerebrospinal fluid Aβ ratios in preclinical Alzheimer’s disease
AUC | SE | 95 % CI | Cutoffa | Sensitivity (%) | Specificity (%) | Correctly classifiedb (%) | |
---|---|---|---|---|---|---|---|
Aβ42 | 0.935 | 0.0394 | 0.806–0.989 | 853 | 100 | 83.87 | 87 |
ttau | 0.733 | 0.132 | 0.565–0.863 | 352 | 71.43 | 77.42 | 76 |
ptau | 0.675 | 0.139 | 0.504–0.818 | 86 | 42.86 | 93.55 | 84 |
Aβ42/ttau | 0.880 | 0.0878 | 0.734–0.963 | 2.258 | 85.71 | 90.32 | 89 |
Specificity of 90 % | Sensitivity (%) | 95 % CI | Cutoffa | Differencec (%) | P valued | Correctly classifiedb (%) | |
Aβ42 | 85.71 | 11.54–100.00 | 798 | 7.90 | 0.25 | 89 | |
ttau | 57.14 | 14.29–100.00 | 465 | 10.53 | 0.125 | 82 | |
ptau | 42.96 | 0.00–85.71 | 87 | 5.26 | 0.5 | 79 | |
Aβ42/ttau | 85.71 | 28.57–100.00 | 2.263 | 0 | 1 | 89 | |
Specificity of 95 % | Sensitivity (%) | 95 % CI | Cutoffa | Differencec (%) | P valued | Correctly classifiedb (%) | |
Aβ42 | 42.86 | 4.05–100.00 | 672 | 21.05 | 0.008 | 87 | |
ttau | 14.29 | 0.00–85.71 | 566 | 23.69 | 0.004 | 82 | |
ptau | 28.57 | 0.00–71.43 | 94 | 2.63 | 1 | 82 | |
Aβ42/ttau | 71.43 | 8.71–100.00 | 2.093 | 7.90 | 0.25 | 92 |