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Table 3 Regression coefficients in linear regression models of factors associated with total MTA score

From: Hippocampal atrophy but not white-matter changes predicts the long-term cognitive response to cholinesterase inhibitors in Alzheimer’s disease

Model B (95 % CI) β P-value Adjusted R2
I Total WMH score 0.202 (0.147 ~ 0.258) 0.361 <0.0005 0.128
II Total WMH score 0.181 (0.124 ~ 0.237) 0.323 <0.0005 0.150
Baseline CDR 0.728 (0.275 ~ 1.182) 0.162 0.002
III Total WMH score 0.186 (0.130 ~ 0.242) 0.332 <0.0005 0.173
Baseline CDR 0.822 (0.371 ~ 1.273) 0.183 <0.0005
Education (year) 0.053 (0.020 ~ 0.086) 0.160 0.001
IV Total WMH score 0.187 (0.133 ~ 0.242) 0.334 <0.0005 0.207
Baseline CDR 0.406 (−0.028 ~ 0.894) 0.090 0.102
Education (year) 0.086 (0.051 ~ 0.122) 0.260 <0.0005
Baseline TMSE −0.099 (−0.149 ~ −0.050) −0.240 <0.0005
V Total WMH score 0.197 (0.143 ~ 0.250) 0.351 <0.0005 0.203
Education (year) 0.089 (0.053 ~ 0.125) 0.268 <0.0005
Baseline TMSE −0.117 (−0.162 ~ −0.072) −0.282 <0.0005
  1. CDR Clinical Dementia Rating, ChEI cholinesterase inhibitor, MTA medial temporal atrophy, TMSE Taiwanese Mini-Mental State Examination, WMH white matter hyperintensity, CI confidence interval; Variables entered into stepwise linear regression analysis: age of starting ChEI, educational level, baseline TMSE, baseline CDR, and total WMH score