Hippocampal atrophy but not white-matter changes predicts the long-term cognitive response to cholinesterase inhibitors in Alzheimer’s disease

Table 3 Regression coefficients in linear regression models of factors associated with total MTA score

Model		B (95 % CI)	β	P-value	Adjusted R²
I	Total WMH score	0.202 (0.147 ~ 0.258)	0.361	<0.0005	0.128
II	Total WMH score	0.181 (0.124 ~ 0.237)	0.323	<0.0005	0.150
II	Baseline CDR	0.728 (0.275 ~ 1.182)	0.162	0.002	0.150
III	Total WMH score	0.186 (0.130 ~ 0.242)	0.332	<0.0005	0.173
	Baseline CDR	0.822 (0.371 ~ 1.273)	0.183	<0.0005
	Education (year)	0.053 (0.020 ~ 0.086)	0.160	0.001
IV	Total WMH score	0.187 (0.133 ~ 0.242)	0.334	<0.0005	0.207
	Baseline CDR	0.406 (−0.028 ~ 0.894)	0.090	0.102
	Education (year)	0.086 (0.051 ~ 0.122)	0.260	<0.0005
	Baseline TMSE	−0.099 (−0.149 ~ −0.050)	−0.240	<0.0005
V	Total WMH score	0.197 (0.143 ~ 0.250)	0.351	<0.0005	0.203
	Education (year)	0.089 (0.053 ~ 0.125)	0.268	<0.0005
	Baseline TMSE	−0.117 (−0.162 ~ −0.072)	−0.282	<0.0005

CDR Clinical Dementia Rating, ChEI cholinesterase inhibitor, MTA medial temporal atrophy, TMSE Taiwanese Mini-Mental State Examination, WMH white matter hyperintensity, CI confidence interval; Variables entered into stepwise linear regression analysis: age of starting ChEI, educational level, baseline TMSE, baseline CDR, and total WMH score

ISSN: 1758-9193