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Inclusion criteria
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1.
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Men who played American football or ice hockey at the professional or Olympic level or who played at the collegiate, semiprofessional, or junior level for at least 2 years
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2.
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Men who played a high-risk contact sport, other than American football or ice hockey, at the professional or Olympic level
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3.
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Women who played a high-risk contact sport at the professional, Olympic, or collegiate level
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4.
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Men or women who played a high-risk contact sport at the professional, Olympic, collegiate, or high school level who died before the age of 35 years
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5.
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Men or women who played a high-risk contact sport at the professional, Olympic, collegiate, or high school level who were diagnosed with ALS during life
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6.
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Men or women with a military history of combat exposure
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7.
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Women with a history of domestic abuse
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Exclusion criteria
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1.
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Specimen with a postmortem interval before fixation of longer than 72 h
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2.
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Specimen that was embalmed following brain autopsy
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3.
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Specimen of less than one full hemisphere
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