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Table 2 Pharmacokinetics of ibuprofen in humans (800 mg) and monkeys (100 mg/kg) after acute treatment

From: Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

  Human (n = 7) Monkey (n = 5)
Plasma CSF Plasma
Cmax total (μM)a 441.63 ± 113.84 12.24 ± 8.18 1060.33 ± 565.25
AUC0–8h (μM*h) 831.44 ± 155.92 36.36 ± 11.75 3744.8 ± 924.16
CSF:plasma ratio   0.01 ± 0.004
  1. aTotal concentration (bound and unbound). AUC 0–8h area under the curve from 0 to 8 h, C max maximum average concentration, CSF cerebrospinal fluid