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Table 2 Pharmacokinetics of ibuprofen in humans (800 mg) and monkeys (100 mg/kg) after acute treatment

From: Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

 

Human (n = 7)

Monkey (n = 5)

Plasma

CSF

Plasma

Cmax total (μM)a

441.63 ± 113.84

12.24 ± 8.18

1060.33 ± 565.25

AUC0–8h (μM*h)

831.44 ± 155.92

36.36 ± 11.75

3744.8 ± 924.16

CSF:plasma ratio

 

0.01 ± 0.004

  1. aTotal concentration (bound and unbound). AUC 0–8h area under the curve from 0 to 8 h, C max maximum average concentration, CSF cerebrospinal fluid
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Alzheimer's Research & Therapy

ISSN: 1758-9193