Global Clinical Status (CIBIC-Plus): Snapshot and AUC analysis
aIn panels A and B, statistical comparisons are made between groups; in C and D, statistical comparisons are made with respect to no change from baseline (zero change from baseline) and zero AUC, respectively. bAUC values corrected for interval duration (four or six weeks). *P <0.05 **P <0.01 ***P <0.001. AUC, area under the curve; CIBIC-Plus, Clinician’s Interview-Based Impression of Change – Plus Caregiver Input; LS, least squares; MEM, memantine; MEM-DON, memantine added to background donepezil treatment; PBO, placebo; PBO-DON, placebo added to background donepezil treatment; SE, standard error of the mean.