Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort

Table 2 Comparison of apolipoprotein E levels among different clinical classification and sex categories

Categories	Total	Non-ε4 carriers	ε4 carriers	P crude ^a	P adj ^a
Total ApoE levels (mg/dl)	6.75 ± 3.00	7.41 ± 3.11	5.59 ± 2.40	<0.001	<0.001^b
Total ApoE levels (HC)	6.97 ± 3.02	7.45 ± 3.10	5.65 ± 2.37	<0.001	<0.001^b
Total ApoE levels (MCI)	6.17 ± 3.02	6.96 ± 3.37	5.02 ± 1.97	0.005	0.005^b
Total ApoE levels (AD)	6.20 ± 2.81	7.39 ± 3.05	5.65 ± 2.53	<0.001	<0.001^b
Total ApoE levels (female)	7.21 ± 3.10	7.91 ± 3.18	5.94 ± 2.87	<0.001	<0.001^c
Total ApoE levels (male)	6.12 ± 2.74	6.70 ± 2.49	5.12 ± 2.18	<0.001	<0.001^c

AD, Alzheimer’s disease; HC, Healthy controls; MCI, Mild cognitive impairment, ^aComparison between apolipoprotein E (APOE)-ε4 carriers and non-ε4 carriers. ^b P-values adjusted after controlling for age and sex. ^c P-values adjusted after controlling for age.

ISSN: 1758-9193